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伴放线放线杆菌菌株Y4和N27通过独特的机制黏附于羟基磷灰石。

Actinobacillus actinomycetemcomitans strains Y4 and N27 adhere to hydroxyapatite by distinctive mechanisms.

作者信息

Kagermeier A S, London J

出版信息

Infect Immun. 1985 Mar;47(3):654-8. doi: 10.1128/iai.47.3.654-658.1985.

DOI:10.1128/iai.47.3.654-658.1985
PMID:3972445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC261347/
Abstract

Actinobacillus actinomycetemcomitans strains Y4 and N27 absorb to spheroidal hydroxyapatite in roughly the same numbers per milligram of substrate and with the same tenacity as two previously tested Cytophaga species. Although the two strains of A. actinomycetemcomitans exhibited similar affinities and number of binding sites for SHA, their response to enzyme treatment and heating were very different. The capacity of strain Y4 to attach to spheroidal hydroxyapatite was diminished by treatment with proteases and phospholipases and was unaffected by neuraminidase, while strain N27 was unaffected by proteases and phospholipases and lost its binding capabilities when treated with neuraminidase.

摘要

伴放线放线杆菌菌株Y4和N27吸附到球状羟基磷灰石上的数量大致相同,每毫克底物的吸附数量以及吸附强度与之前测试的两种噬纤维菌属细菌相同。虽然两株伴放线放线杆菌对球状羟基磷灰石表现出相似的亲和力和结合位点数,但它们对酶处理和加热的反应却非常不同。用蛋白酶和磷脂酶处理后,菌株Y4附着到球状羟基磷灰石上的能力减弱,而神经氨酸酶处理对其无影响;而菌株N27不受蛋白酶和磷脂酶影响,但经神经氨酸酶处理后会丧失其结合能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9f3/261347/971673971893/iai00120-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9f3/261347/971673971893/iai00120-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9f3/261347/971673971893/iai00120-0083-a.jpg

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本文引用的文献

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Infect Immun. 1980 Aug;29(2):768-77. doi: 10.1128/iai.29.2.768-777.1980.
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Human immune responses to oral micro-organisms. I. Association of localized juvenile periodontitis (LJP) with serum antibody responses to Actinobacillus actinomycetemcomitans.人类对口腔微生物的免疫反应。I. 局限性青少年牙周炎(LJP)与针对伴放线放线杆菌的血清抗体反应的关联。
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Hydrophobicity and adherence of oral streptococci after repeated subculture in vitro.
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Nonspecific adherence and fibril biogenesis by Actinobacillus actinomycetemcomitans: TadA protein is an ATPase.伴放线放线杆菌的非特异性黏附与菌毛生物合成:TadA蛋白是一种ATP酶。
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Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea.伴放线放线杆菌的非特异性黏附需要在细菌和古细菌中广泛存在的基因。
J Bacteriol. 2000 Nov;182(21):6169-76. doi: 10.1128/JB.182.21.6169-6176.2000.
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