Moran D M, Cottam G P, Standring R, Cook R M
Int Arch Allergy Appl Immunol. 1985;76(3):261-5. doi: 10.1159/000233702.
The ability of lymphocytes obtained from mice treated with whole rye grass pollen extract or purified major allergen components (R7--apparent molecular weight 31,000; R14a-apparent molecular weight 11,000) to proliferate in culture on challenge with these allergens has been studied. Whole rye grass pollen extract was found to stimulate responses with lymphocytes from all treated but not non-treated animals, whereas the purified allergens failed to effect proliferation except with cells obtained from animals treated with the homologous allergen. These results accord with previous observations that, of the antigen present in the whole rye grass pollen extract, the components showing greatest immunogenicity in murine systems are not those commonly regarded as being the major allergens in man. The mouse may not thus provide a relevant model of human immune responses to rye grass pollen extracts.
研究了从用全黑麦草花粉提取物或纯化的主要过敏原成分（R7——表观分子量31,000；R14a——表观分子量11,000）处理过的小鼠中获得的淋巴细胞在受到这些过敏原刺激时在培养物中增殖的能力。发现全黑麦草花粉提取物能刺激所有经处理但未经处理动物的淋巴细胞产生反应，而纯化的过敏原除了对用同源过敏原处理过的动物获得的细胞外，未能影响增殖。这些结果与先前的观察结果一致，即在全黑麦草花粉提取物中存在的抗原中，在小鼠系统中显示出最大免疫原性的成分并非通常被认为是人类主要过敏原的那些成分。因此，小鼠可能无法提供人类对黑麦草花粉提取物免疫反应的相关模型。
