Zeng Fu, Shao Yuwen, Wu Jingyi, Luo Jingwen, Yue Ying, Shen Yang, Wang Yanghanzhao, Shi Yuxin, Wu Dan, Cata Juan P, Yang Shuofei, Zhang Hao, Miao Changhong
Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China.
Department of Anesthesiology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China.
Cancer Lett. 2024 Dec 24;611:217413. doi: 10.1016/j.canlet.2024.217413.
Although surgical resection of tumor mass remains the mainstay of curative therapeutic management for solid tumors, accumulating studies suggest that these procedures promote tumor recurrence and metastasis. Regarded as the first immune cells to fight against infectious or inflammatory insults from surgery, neutrophils along with their ability of neutrophil extracellular traps (NETs) production has attracted much attention. A growing body of evidence suggests that NETs promote cancer metastasis by stimulating various stages, including local invasion, colonization, and growth. Therefore, we discussed the mechanism of NETosis induced by surgical stress and tumor cells, and the contribution of NETs on tumor metastasis: aid in the tumor cell migration and proliferation, evasion of immune surveillance, circulating tumor cell adhesion and establishment of a metastatic niche. Lastly, we summarized existing NET-targeting interventions, offering recent insights into potential targets for clinical intervention.
尽管手术切除肿瘤块仍是实体瘤根治性治疗的主要手段，但越来越多的研究表明，这些手术会促进肿瘤复发和转移。中性粒细胞作为对抗手术引起的感染或炎症损伤的首批免疫细胞，及其产生中性粒细胞胞外陷阱（NETs）的能力已引起广泛关注。越来越多的证据表明，NETs通过刺激包括局部侵袭、定植和生长在内的各个阶段来促进癌症转移。因此，我们讨论了手术应激和肿瘤细胞诱导NETosis的机制，以及NETs对肿瘤转移的作用：协助肿瘤细胞迁移和增殖、逃避免疫监视、循环肿瘤细胞黏附以及建立转移微环境。最后，我们总结了现有的NET靶向干预措施，为临床干预的潜在靶点提供了最新见解。
