Quinn Orlagh, King Grace, Hoban Ann, Sawyer Clare, Douglas Amy, Painset Anaïs, Charlett Andre, Nelson Andrew, Rees Carys, Byers Chloe, Williams Christopher, Brown Colin, Mohan Kitty, Brown Claire, Jenkins Claire, Neill Claire, Leckenby Genna, Larkin Lesley, Allison Lesley, Olufon Oluwakemi, Nickbakhsh Sema, Mannes Trish, Inns Thomas, Balasegaram Sooria
UK Health Security Agency, London, UK.
Public Health Wales, Cardiff, UK.
Epidemiol Infect. 2024 Dec 27;152:e179. doi: 10.1017/S0950268824001729.
Shiga toxin-producing (STEC) is a group of bacteria that causes gastrointestinal illness and occasionally causes large foodborne outbreaks. It represents a major public health concern due to its ability to cause severe illness which can sometimes be fatal. This study was undertaken as part of a rapid investigation into a national foodborne outbreak of STEC O145. On 22 May 2024, United Kingdom (UK) public health agencies and laboratories identified an increase in stool specimens submissions and patients testing positive for Shiga toxin-producing (STEC). Whole genome sequencing (WGS) identified serotype O145:H28 belonging to the same five single nucleotide polymorphism (SNP) single linkage cluster as the causative agent. By 3 July 2024, 288 cases had been linked to the cluster. Most cases were adults (87%) and females (57%), 49% were hospitalized with a further 10% attending emergency care. Descriptive epidemiology and analytical studies were conducted which identified consumption of nationally distributed pre-packed sandwiches as a common food exposure. The implicated food business operators voluntarily recalled ready-to-eat sandwiches and wraps containing lettuce on 14 June 2024.
产志贺毒素大肠杆菌（STEC）是一类可引发胃肠道疾病并偶尔导致大规模食源性疾病暴发的细菌。因其能够引发有时可能致命的严重疾病，它成为了一个重大的公共卫生问题。本研究是对一起全国性的STEC O145食源性疾病暴发进行快速调查的一部分。2024年5月22日，英国公共卫生机构和实验室发现，提交的粪便样本数量有所增加，且产志贺毒素大肠杆菌检测呈阳性的患者增多。全基因组测序（WGS）确定血清型O145:H28与病原体属于同一个五个单核苷酸多态性（SNP）单连锁簇。截至2024年7月3日，已有288例病例与该簇有关联。大多数病例为成年人（87%）且为女性（57%），49%的病例住院治疗，另有10%前往急诊。开展了描述性流行病学和分析性研究，确定食用全国范围内销售的预包装三明治是常见的食物暴露因素。涉案食品企业经营者于2024年6月14日自愿召回了含有生菜的即食三明治和卷饼。
