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流行病学调查发现了一起与预包装三明治有关的产志贺毒素血清型 O26:H11 爆发。

Epidemiological investigations identified an outbreak of Shiga toxin-producing serotype O26:H11 associated with pre-packed sandwiches.

机构信息

National Infection Service, Public Health England, London, UK.

Scottish E. coli O157/STEC Reference Laboratory, Edinburgh, UK.

出版信息

Epidemiol Infect. 2021 Aug 10;149:e178. doi: 10.1017/S0950268821001576.

DOI:10.1017/S0950268821001576
PMID:34635196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8365849/
Abstract

In October 2019, public health surveillance systems in Scotland identified an increase in the number of reported infections of Shiga toxin-producing Escherichia coli (STEC) O26:H11 involving bloody diarrhoea. Ultimately, across the United Kingdom (UK) 32 cases of STEC O26:H11 stx1a were identified, with the median age of 27 years and 64% were male; six cases were hospitalised. Among food exposures there was an association with consuming pre-packed sandwiches purchased at outlets belonging to a national food chain franchise (food outlet A) [odds ratio (OR) = 183.89, P < 0.001]. The common ingredient identified as a component of the majority of the sandwiches sold at food outlet A was a mixed salad of Apollo and Iceberg lettuce and spinach leaves. Microbiological testing of food and environmental samples were negative for STEC O26:H11, although STEC O36:H19 was isolated from a mixed salad sample taken from premises owned by food outlet A. Contamination of fresh produce is often due to a transient event and detection of the aetiological agent in food that has a short-shelf life is challenging. Robust, statistically significant epidemiological analysis should be sufficient evidence to direct timely and targeted on-farm investigations. A shift in focus from testing the microbiological quality of the produce to investigating the processes and practices through the supply chain and sampling the farm environment is recommended.

摘要

2019 年 10 月,苏格兰公共卫生监测系统发现报告的产志贺毒素大肠杆菌(STEC)O26:H11 感染病例数增加,涉及血性腹泻。最终,在英国(UK)共发现 32 例 STEC O26:H11 stx1a,中位年龄为 27 岁,64%为男性;6 例住院。在食物暴露方面,与食用在全国连锁食品店(食品店 A)购买的预包装三明治有关(比值比(OR)=183.89,P<0.001)。在食品店 A 出售的大多数三明治中,共同的成分是一种由 Apollo 和冰山生菜以及菠菜叶混合的沙拉。对食物和环境样本的微生物检测均未发现 STEC O26:H11,但从食品店 A 所有的混合沙拉样本中分离出了 STEC O36:H19。新鲜农产品的污染通常是由于偶发事件引起的,而且在保质期短的食物中检测到病原体具有挑战性。强有力的、具有统计学意义的流行病学分析应该足以作为证据,及时、有针对性地对农场进行调查。建议从检测农产品的微生物质量转向调查供应链中的流程和做法,并对农场环境进行采样。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87d/8365849/599abd2a9972/S0950268821001576_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87d/8365849/c618c49dc50d/S0950268821001576_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87d/8365849/ecd5ff1157b8/S0950268821001576_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87d/8365849/46981b5ab810/S0950268821001576_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87d/8365849/599abd2a9972/S0950268821001576_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87d/8365849/c618c49dc50d/S0950268821001576_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87d/8365849/ecd5ff1157b8/S0950268821001576_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87d/8365849/46981b5ab810/S0950268821001576_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87d/8365849/599abd2a9972/S0950268821001576_fig4.jpg

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1
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Emerg Infect Dis. 2020 Oct;26(10):2394-2400. doi: 10.3201/eid2610.200319.
2
Shiga toxin-producing haemolytic uraemic syndrome (STEC-HUS): diagnosis, surveillance and public-health management in England.产志贺毒素溶血尿毒综合征(STEC-HUS):英格兰的诊断、监测与公共卫生管理
J Med Microbiol. 2020 Jul;69(7):1034-1036. doi: 10.1099/jmm.0.001215.
3
Antimicrobial resistance in Shiga toxin-producing other than serotype O157 : H7 in England, 2014-2016.
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Epidemiol Infect. 2024 Dec 27;152:e179. doi: 10.1017/S0950268824001729.
4
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Microb Genom. 2024 May;10(5). doi: 10.1099/mgen.0.001243.
5
Unravelling the impact of fat content on the microbial dynamics and spatial distribution of foodborne bacteria in tri-phasic viscoelastic 3D models.揭示脂肪含量对三相黏弹三维模型中食源性病原体微生物动态和空间分布的影响。
Sci Rep. 2023 Dec 9;13(1):21811. doi: 10.1038/s41598-023-48968-8.
6
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7
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8
Impact of whole genome sequencing on the investigation of food-borne outbreaks of Shiga toxin-producing serogroup O157:H7, England, 2013 to 2017.全基因组测序对 2013 至 2017 年英格兰产志贺毒素血清群 O157:H7 食源性暴发调查的影响。
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9
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