Changes in heart rate variability at rest and during exercise in patients after a stroke: a feasibility study.

The aim of this study was to evaluate the feasibility of using a biofeedback-enhanced robotics-assisted tilt table (RATT) to investigate time- and intensity-dependent changes in heart rate variability (HRV) at rest and during heart rate-controlled exercise in patients recovering from a stroke. Twelve patients (age 55.3 years ± 15.6 years, 7 women) completed two separate measurement sessions. The first involved familiarization and system identification to determine parameters of a feedback system for automatic control of heart rate (HR). The second comprised 14 min of rest and 21 min of active exercise during which HR was held constant using feedback control to eliminate cardiovascular drift. HR data were collected using a chest-belt HR sensor, and raw RR intervals were employed for HRV analysis during periods of rest (0-7 min and 7-14 min) and exercise (5-13 min and 13-21 min). A biofeedback-enhanced, robotics-assisted tilt table can be successfully employed to perform heart rate-controlled exercises in patients after a stroke. All HRV metrics were substantially lower during exercise compared to rest. In the rest period, HRV values during 0-7 min were lower than during 7-14 min, in line with a slight HR decrease over the entire rest period. During exercise, HRV values during 5-13 min were higher than during 13-21 min, suggesting a time-dependent HRV decrease. All HRV metrics exhibited intensity- and time-dependent changes: higher HRV at rest and decreasing HRV over time. Understanding these HRV characteristics will support the development of heart rate-controlled exercise regimens and protocols for examining HRV changes during exercise in patients.