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葡萄牙的人体片形吸虫病:一例报告。

Human Fascioliasis in Portugal: A Case Report.

作者信息

Pereira Sara, Cerqueira Paula, Azevedo Sabina, Sousa Bárbara, Faraldo Selmira

机构信息

Internal Medicine, Hospital Conde de Bertiandos, Unidade Local de Saúde do Alto Minho, Ponte de Lima, PRT.

Internal Medicine, Hospital Distrital de Santarém, Santarém, PRT.

出版信息

Cureus. 2024 Nov 26;16(11):e74527. doi: 10.7759/cureus.74527. eCollection 2024 Nov.

DOI:10.7759/cureus.74527
PMID:39726513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11671162/
Abstract

Fascioliasis is a zoonotic disease that may affect humans as incidental hosts after the ingestion of contaminated water or aquatic plants. Despite the non-specificity of its signs and symptoms, a triad of abdominal pain, fever, and peripheral eosinophilia should increase suspicion. The diagnosis of fascioliasis can be particularly difficult in non-endemic countries. It presents a worldwide but heterogeneous distribution, according to several environmental and human activity-related factors. Few cases have been described in Portugal. The authors report the case of a 48-year-old man presenting with abdominal pain, fever, and nighttime sweating. The CT scan revealed multiple hepatic nodules, which were then confirmed as abscesses in the context of hepatic fascioliasis. We aim to alert for the persistence of a few autochthonous cases of human fascioliasis in Portugal, the need to maintain a high degree of suspicion for this disease despite its non-specific presentation, and the emergence of triclabendazole resistance.

摘要

肝片吸虫病是一种人畜共患病,人类在摄入受污染的水或水生植物后可能作为偶然宿主受到感染。尽管其体征和症状缺乏特异性,但腹痛、发热和外周嗜酸性粒细胞增多三联征应增加怀疑。在非流行国家,肝片吸虫病的诊断可能特别困难。根据一些与环境和人类活动相关的因素,该病在全球范围内分布,但分布不均。葡萄牙报道的病例很少。作者报告了一例48岁男性,表现为腹痛、发热和夜间盗汗。CT扫描显示多个肝结节,随后在肝片吸虫病的背景下确诊为脓肿。我们旨在提醒注意葡萄牙仍有少数本土人类肝片吸虫病病例,尽管该病表现缺乏特异性,但仍需高度怀疑,同时要注意三氯苯达唑耐药性的出现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f676/11671162/42e97d7682b5/cureus-0016-00000074527-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f676/11671162/e980fe84fcbb/cureus-0016-00000074527-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f676/11671162/6a2726fd8541/cureus-0016-00000074527-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f676/11671162/42e97d7682b5/cureus-0016-00000074527-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f676/11671162/e980fe84fcbb/cureus-0016-00000074527-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f676/11671162/6a2726fd8541/cureus-0016-00000074527-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f676/11671162/42e97d7682b5/cureus-0016-00000074527-i03.jpg

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1
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本文引用的文献

1
Effects of temperature on the life history traits of intermediate host snails of fascioliasis: A systematic review.温度对片形吸虫中间宿主蜗牛生活史特征的影响:系统评价。
PLoS Negl Trop Dis. 2023 Dec 4;17(12):e0011812. doi: 10.1371/journal.pntd.0011812. eCollection 2023 Dec.
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The global prevalence of human fascioliasis: a systematic review and meta-analysis.全球人体片形吸虫病的流行率:一项系统评价和荟萃分析。
Ther Adv Infect Dis. 2023 Jul 8;10:20499361231185413. doi: 10.1177/20499361231185413. eCollection 2023 Jan-Dec.
3
Imaging findings of human hepatic fascioliasis: a case report and review of the literature.
人肝片形吸虫病的影像学表现:病例报告及文献复习。
J Med Case Rep. 2021 Jun 24;15(1):324. doi: 10.1186/s13256-021-02945-9.
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Hepatic fascioliasis as an important differential diagnosis to cholangiocarcinoma.
J Travel Med. 2021 Aug 27;28(6). doi: 10.1093/jtm/taab061.
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Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control.人体肝片吸虫病:当前的流行病学现状以及诊断、治疗和控制策略
Res Rep Trop Med. 2020 Nov 26;11:149-158. doi: 10.2147/RRTM.S237461. eCollection 2020.
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Triclabendazole for the treatment of human fascioliasis and the threat of treatment failures.三氯苯达唑治疗人体片形吸虫病及治疗失败的威胁。
Expert Rev Anti Infect Ther. 2021 Jul;19(7):817-823. doi: 10.1080/14787210.2021.1858798. Epub 2020 Dec 14.
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Parasitology. 2021 Apr;148(4):385-407. doi: 10.1017/S0031182020002255. Epub 2020 Dec 2.
8
Treatment failure after multiple courses of triclabendazole in a Portuguese patient with fascioliasis.一名葡萄牙肝片吸虫病患者在接受多疗程三氯苯达唑治疗后出现治疗失败。
BMJ Case Rep. 2020 Mar 18;13(3):e232299. doi: 10.1136/bcr-2019-232299.
9
Drug resistance in liver flukes.肝吸虫耐药性。
Int J Parasitol Drugs Drug Resist. 2020 Apr;12:39-59. doi: 10.1016/j.ijpddr.2019.11.003. Epub 2020 Jan 10.
10
Triclabendazole in the treatment of human fascioliasis: a review.三氯苯达唑治疗人体片形吸虫病:综述。
Trans R Soc Trop Med Hyg. 2019 Dec 1;113(12):797-804. doi: 10.1093/trstmh/trz093.