Li Qiuying, Li Xinyan, He Sheng, Li Jiao
Department of Ultrasonography, Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, China.
Graduate School, Guangxi University of Chinese Medicine, Nanning, China.
Front Pediatr. 2024 Dec 11;12:1467760. doi: 10.3389/fped.2024.1467760. eCollection 2024.
to evaluate the research status and development hotspots of fetal α-thalassemia by quantitatively analyzing the diagnostic status, key areas, related management measures and prospects of the disease by bibliometrics.
The global literature on fetal α-thalassemia and severe α-thalassemia from 2009-2023 in the Web of Science Core Collection (WOSCC) was visually analyzed by VOSviewer and CiteSpace.
(1) The examination of the quantity of publications concerning fetal α-thalassemia indicates a rising tendency prior to 2018, followed by a decrease after 2018. (2)The United States, China, Italy, Thailand have published more papers, and the United States has more collaborating countries such as Italy and China. (3) Chiang Mai University and Harvard University are the top two institutions with the highest contribution. However, Chiang Mai University's H index (12) and citation frequency per article (8.05) are relatively low and the NC (6,342), H index (33) and citations per article (75.42) of Harvard University are higher than those of the other institutions. (4) Tongsong T, Gambari R and Fucharoen S are the top three prolific authors. Fucharoen S emerges as the most frequently cited author with 738 citations, excluding self-citations. (5) HEMOGLOBIN leading with 87 published papers (NC:601,IF: 0.82, H-index: 13), followed by BLOOD(58 papers, Nc: 3755, IF: 25.48, H-index: 40) and BLOOD CELLS MOLECULES AND DISEASES(39 papers, Nc: 729, IF: 2.37, H-index: 16). (6) The most cited article was published in science and the second and third cited articles were featured in the Proceedings of the National Academy of Sciences; the top 3 clusters of co-cited literature are "gene editing", "polymorphisms", "hydroxyurea". (7) Keywords analysis showe that the top two categories of keyword cluster focus on the prenatal diagnosis and the current treatment strategy of the disease, which remain the research hotspots.
Recent research on this topic has primarily focused on prenatal diagnosis and treatment strategies. A particular area of interest is the ongoing research on gene therapy.The advances in non-invasive diagnosis and therapeutic methods will change the current management approaches for fetal severe α-thalassemia in the future.
通过文献计量学定量分析胎儿α地中海贫血的诊断现状、关键领域、相关管理措施及前景，以评估胎儿α地中海贫血的研究现状与发展热点。
利用VOSviewer和CiteSpace对Web of Science核心合集（WOSCC）中2009 - 2023年关于胎儿α地中海贫血和重型α地中海贫血的全球文献进行可视化分析。
（1）关于胎儿α地中海贫血的出版物数量在2018年之前呈上升趋势，之后呈下降趋势。（2）美国、中国、意大利、泰国发表的论文较多，美国有更多的合作国家，如意大 利和中国。（3）清迈大学和哈佛大学是贡献最大的前两个机构。然而，清迈大学的H指数（12）和每篇文章的被引频次（8.05）相对较低，哈佛大学的发文量（6342）、H指数（33）和每篇文章的被引频次（75.42）高于其他机构。（4）Tongsong T、Gambari R和Fucharoen S是发文量最多的前三位作者。Fucharoen S是被引频次最高的作者，排除自引后有738次被引。（5）《血红蛋白》发表论文87篇（发文量：601，影响因子：0.82，H指数：13）领先，其次是《血液》（58篇论文，发文量：3755，影响因子：25.48，H指数：40）和《血细胞、分子与疾病》（39篇论文，发文量：729，影响因子：2.37，H指数：16）。（6）被引次数最多的文章发表在《科学》杂志上，第二和第三被引文章发表在《美国国家科学院院刊》上；共被引文献的前3个聚类是“基因编辑”“多态性”“羟基脲”。（7）关键词分析表明，关键词聚类的前两类聚焦于该疾病的产前诊断和当前治疗策略，这仍然是研究热点。
该主题的近期研究主要集中在产前诊断和治疗策略上。一个特别感兴趣的领域是正在进行的基因治疗研究。非侵入性诊断和治疗方法的进展将在未来改变胎儿重型α地中海贫血的当前管理方法。
