Mänd Sarah-Ålivia, Sjöholm Åke
Department of Internal Medicine, Gävle Hospital, SE-80324 Gävle, Sweden.
Department of Internal Medicine, Division of Endocrinology and Diabetology, Gävle Hospital, University of Gävle, SE-80324 Gävle, Sweden.
JCEM Case Rep. 2024 Dec 26;3(1):luae244. doi: 10.1210/jcemcr/luae244. eCollection 2025 Jan.
Androgen secretion by testicular germ-cell tumors (GCTs) appears to be markedly rare and likely underreported in the literature. This case study highlights a patient with such a rare tumor, underscoring a notable and yet easily avoidable diagnostic oversight in one of the most prevalent cancers among men. We advocate for increased vigilance and the inclusion of specific symptomatic screening for hyperandrogenism of select patients in existing guidelines and, where appropriate, the implementation of standardized hormonal laboratory analyses in both pre- and post-orchidectomy assessments. These measures could enhance the reporting of cases, standardize care, and improve understanding of the underlying mechanisms of these rare tumors. Finally, future studies should explore the implications of androgen secretion for the prognosis and treatment of GCTs.
睾丸生殖细胞肿瘤（GCTs）分泌雄激素的情况似乎极为罕见，且在文献中可能未得到充分报道。本病例研究着重介绍了一名患有此类罕见肿瘤的患者，凸显了男性中最常见癌症之一中一个显著但又容易避免的诊断疏忽。我们主张提高警惕，在现有指南中纳入对特定患者雄激素过多症状的筛查，并在适当情况下，在睾丸切除术前和术后评估中实施标准化的激素实验室分析。这些措施可增加病例报告，规范治疗，并增进对这些罕见肿瘤潜在机制的了解。最后，未来的研究应探讨雄激素分泌对GCTs预后和治疗的影响。
