高血压发病年龄与慢性肾脏病的关系：一项美国人群的横断面研究。
The relationship between the age of onset of hypertension and chronic kidney disease: a cross-sectional study of the American population.
作者信息
Qiu Lanlan, Wu Bo
机构信息
Department of Cardiology, Longyan People's Hospital, Longyan, Fujian, China.
Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
出版信息
Front Cardiovasc Med. 2024 Dec 12;11:1426953. doi: 10.3389/fcvm.2024.1426953. eCollection 2024.
BACKGROUND
Hypertension can damage multiple target organs. The younger the age of onset of hypertension is, the greater the risk of cardiovascular disease (CVD) and cardiovascular death. Chronic kidney disease (CKD) is a complication of hypertension, but few studies have investigated the relationship between the age of onset of hypertension and CKD.
OBJECTIVE
We investigated the relationship between the age of onset of hypertension and CKD.
METHOD
We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. A total of 30,613 participants were assigned to one of four groups. Group 1, no hypertension ( = 19,516); Group 2, age of onset <35 years ( = 2,180); Group 3, 35≤ age of onset <45 years ( = 2,128); and Group 4, age of onset ≥45 years ( = 6,789). Logistic regression analysis was used to evaluate the relationship between the age of onset of hypertension and CKD.
RESULTS
After adjusting for potential confounders, a younger age at onset of hypertension was associated with a greater risk of developing CKD compared with the absence of hypertension (Group 2 OR: 2.52, 95% CI: 1.53-4.14, < 0.001; Group 3 OR: 1.59, 95% CI: 1.01-2.51, = 0.048; Group 4 OR: 1.54, 95% CI: 1.00-2.38, = 0.050).
CONCLUSIONS
There was a strong association between the age of onset of hypertension and CKD. The younger the age of onset of hypertension is, the greater the risk of CKD.
背景
高血压会损害多个靶器官。高血压发病年龄越小，患心血管疾病（CVD）和心血管死亡的风险就越大。慢性肾脏病（CKD）是高血压的一种并发症，但很少有研究探讨高血压发病年龄与CKD之间的关系。
目的
我们研究了高血压发病年龄与CKD之间的关系。
方法
我们分析了2007 - 2018年美国国家健康与营养检查调查（NHANES）的数据。总共30613名参与者被分为四组之一。第1组，无高血压（n = 19516）；第2组，发病年龄<35岁（n = 2180）；第3组，35≤发病年龄<45岁（n = 2128）；第4组，发病年龄≥45岁（n = 6789）。采用逻辑回归分析来评估高血压发病年龄与CKD之间的关系。
结果
在对潜在混杂因素进行调整后，与无高血压相比，高血压发病年龄越小，发生CKD的风险越高（第2组OR：2.52，95%CI：1.53 - 4.14，P<0.001；第3组OR：1.59，95%CI：1.01 - 2.51，P = 0.048；第4组OR：1.54，95%CI：1.00 - 2.38，P = 0.050）。
结论
高血压发病年龄与CKD之间存在密切关联。高血压发病年龄越小，患CKD 的风险越高。
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