Pollmann D S, Koch B A, Seitz L M, Mohr H E, Kennedy G A
J Anim Sci. 1985 Jan;60(1):239-47. doi: 10.2527/jas1985.601239x.
Two studies were conducted using Fusarium graminearum-infected (scabby) wheat containing 6.8 ppm deoxynivalenol (DON), commonly called vomitoxin, substituted for normal wheat in starter pig diets to give varying levels of DON. After 3 wk on experimental treatments, one-half of the pigs in trial one were sacrificed to evaluate the effects of DON on heart, kidney, spleen and liver. Analyses for DON residues in these tissues were also performed. The remaining 16 pigs were placed on a conventional diet for 4 wk to evaluate effects of DON on subsequent animal performance. A different sample of scabby wheat containing 4.9 ppm of DON was substituted for sorghum grain in growing-finishing pig diets to give varying concentrations of DON. At the end of the 42-d feeding period, eight pigs were slaughtered to evaluate the effects of DON on selected tissues. Results of the three trials suggest that feed intake was reduced when DON concentrations in the swine diets neared or exceeded 1 ppm. No apparent signs of disease, including vomiting, were observed in experimental animals. Histological evaluation revealed no significant lesions or abnormalities related to DON ingestion in tissues examined. Traces of DON (8 to 28 ppb, wet weight) were found in kidney, liver, spleen and heart of starter pigs consuming the diets containing DON up to time of slaughter. No DON was found in tissues of growing-finishing pigs that were withdrawn from feed about 12 h before slaughter.
进行了两项研究，用含有6.8 ppm脱氧雪腐镰刀菌烯醇（DON）（俗称呕吐毒素）的禾谷镰刀菌感染（结痂）小麦替代仔猪日粮中的正常小麦，以提供不同水平的DON。在进行3周的实验处理后，试验一中一半的猪被宰杀，以评估DON对心脏、肾脏、脾脏和肝脏的影响。还对这些组织中的DON残留进行了分析。其余16头猪被置于常规日粮中4周，以评估DON对后续动物性能的影响。用含有4.9 ppm DON的不同样本的结痂小麦替代生长育肥猪日粮中的高粱谷物，以提供不同浓度的DON。在42天的饲喂期结束时，宰杀8头猪以评估DON对选定组织的影响。三项试验的结果表明，当猪日粮中DON浓度接近或超过1 ppm时，采食量会降低。在实验动物中未观察到包括呕吐在内的明显疾病迹象。组织学评估显示，在所检查的组织中，未发现与摄入DON相关的明显病变或异常。在食用含DON日粮直至宰杀时的仔猪的肾脏、肝脏、脾脏和心脏中发现了微量的DON（湿重8至28 ppb）。在宰杀前约12小时停止喂食的生长育肥猪的组织中未发现DON。
