Kamposioras Konstantinos, Ntellas Panagiotis, Dadouli Katerina, Christodoulis Eleftherios, Adamou Marios, Anderson Daniel, Shanthappa Anup, Connell Jacqueline, Williams Joseph, Simpson Lilly, Germetaki Theodora, Braun Michael, Barriuso Jorge, Hasan Jurjees, Mullamitha Saifee, Marti Kalena, Saunders Mark, Lim Kok Haw Jonathan
Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, UK.
Department of Medical Oncology, University Hospital of Ioannina, 45500 Ioannina, Greece.
Curr Oncol. 2024 Dec 11;31(12):7903-7913. doi: 10.3390/curroncol31120582.
PICO-SM was a prospective longitudinal study investigating the psychological impact of the COVID-19 pandemic on patients with colorectal cancer treated in a large UK tertiary cancer centre. Here, we present the impact of the third wave of the pandemic (December 2021 to February 2022), when the Omicron variant became prevalent in the UK, and the complete longitudinal comparison across the entire duration of this study. Patients were invited to complete a questionnaire, including screening psychometric tools. In total, n = 312 patients were included in the final analysis. Specifically, in this Omicron-predominant wave, n = 96 patients were studied in detail: the mean age was 64 years, 64% were male, 33% reported poor well-being, 27% anxiety, 11% depressive symptoms, and 3% trauma-related symptoms. The participants who had investigations cancelled (OR 9.22, 95% CI 1.09-77.85; = 0.041) or felt that the pandemic would affect their mental health (OR 3.82, 95% CI 1.96-7.44; < 0.001) had an increased risk of anxiety according to a multivariate analysis. Similarly, independent predictors of poor well-being included concern that the pandemic would affect their cancer treatment (OR 4.59, 95% CI 1.03-20.56; = 0.046) or mental health (OR 3.90, 95% CI 1.38-11.03; = 0.010). The psychological distress experienced by patients, particularly anxiety, remained high during the third wave of the COVID-19 pandemic. These results align with our previously reported findings, emphasising the importance of continuing cancer treatment amidst an ongoing humanitarian emergency.
PICO-SM是一项前瞻性纵向研究，旨在调查新冠疫情对英国一家大型三级癌症中心接受治疗的结直肠癌患者的心理影响。在此，我们呈现了疫情第三波（2021年12月至2022年2月）的影响，当时奥密克戎变种在英国流行，以及在本研究整个期间的完整纵向比较。邀请患者完成一份问卷，包括筛查心理测量工具。最终分析共纳入n = 312名患者。具体而言，在以奥密克戎为主的这一波疫情中，对n = 96名患者进行了详细研究：平均年龄为64岁，64%为男性，33%报告幸福感差，27%有焦虑症状，11%有抑郁症状，3%有创伤相关症状。多因素分析显示，检查被取消的参与者（比值比9.22，95%置信区间1.09 - 77.85；P = 0.041）或认为疫情会影响其心理健康的参与者（比值比3.82，95%置信区间1.96 - 7.44；P < 0.001）焦虑风险增加。同样，幸福感差的独立预测因素包括担心疫情会影响其癌症治疗（比值比4.59，95%置信区间1.03 - 20.56；P = 0.046）或心理健康（比值比3.90，95%置信区间1.38 - 11.03；P = 0.010）。在新冠疫情第三波期间，患者经历的心理困扰，尤其是焦虑，仍然很高。这些结果与我们之前报告的发现一致，强调了在持续的人道主义紧急情况中继续进行癌症治疗的重要性。
