Mahboub Nadine, Ayoub Elissa, Mounzer Carine, Baltagi Tatiana Kate, Papandreou Dimitrios, de Vries Nanne, Rizk Rana
Department of Nutrition and Food Sciences, Faculty of Arts and Sciences, Lebanese International University, Beirut P.O. Box 146404, Lebanon.
Department of Nutrition and Dietetics, Faculty of Public Health Branch 2, Lebanese University, Beirut P.O. Box 6573, Lebanon.
Clin Pract. 2024 Dec 10;14(6):2661-2680. doi: 10.3390/clinpract14060210.
Data about metabolic syndrome (MS) in people who use drugs (PWUD) undergoing treatment for recovery are limited. We aimed to explore the extent of the MS and its predominant components and determinants in a sample of PWUD undergoing treatment for recovery through rehabilitation or opioid substitution treatment (OST) in Lebanon. Furthermore, we investigated the effect of each treatment modality on the MS; This was a cross-sectional study, in which demographics and treatment-related, nutritional, and biochemical data of the participants were collected. MS was defined according to the American Heart Association and the National Heart, Lung, and Blood Institute (AHA/NHLBI) criteria. Descriptive statistics were presented, and bivariate and multivariate analyses were conducted; A total of 155 male subjects with the following characteristics were included: OST: n = 80; rehabilitation: n = 75; mean age: 32.53 ± 8.39 years; mean body mass index (BMI): 27.41 ± 4.99 Kg/m; mean duration of treatment: 18 months. More than half of the sample had low HDL-C (56.8%) and/or elevated blood pressure (51.6%), 42.9% had elevated WC, 21.9% had elevated TG, and 12.3% had elevated FBS. Furthermore, 7.2% of the sample had no components of the MS, 29.2% had one component, 40.9% had two components, 16.9% had three components, and 5.8% had four components. MS was identified in 22.7% of the sample. Higher age was associated with higher odds of being diagnosed with MS (OR = 1.072; 95% CI: 1.021-1.126), whereas higher duration of current treatment was associated with lower odds (OR = 0.969; 95% CI: 0.944-0.995); MS and its components are prevalent in PWUD undergoing treatment for recovery. Routine screening and preventive measures are essential to prevent metabolic syndrome, particularly among older people and treatment newcomers.
关于正在接受康复治疗的吸毒人员（PWUD）代谢综合征（MS）的数据有限。我们旨在探讨黎巴嫩通过康复治疗或阿片类药物替代治疗（OST）接受康复治疗的PWUD样本中MS的程度及其主要组成部分和决定因素。此外，我们研究了每种治疗方式对MS的影响；这是一项横断面研究，收集了参与者的人口统计学、与治疗相关的、营养和生化数据。MS根据美国心脏协会和美国国立心肺血液研究所（AHA/NHLBI）标准定义。给出了描述性统计数据，并进行了双变量和多变量分析；共纳入155名具有以下特征的男性受试者：OST：n = 80；康复治疗：n = 75；平均年龄：32.53±8.39岁；平均体重指数（BMI）：27.41±4.99 Kg/m²；平均治疗持续时间：18个月。超过一半的样本有低高密度脂蛋白胆固醇（HDL-C）（56.8%）和/或血压升高（51.6%），42.9%的人腰围（WC）升高，21.9%的人甘油三酯（TG）升高，12.3%的人空腹血糖（FBS）升高。此外，7.2%的样本没有MS的组成部分，29.2%有一个组成部分，40.9%有两个组成部分，16.9%有三个组成部分，5.8%有四个组成部分。22.7%的样本被确诊患有MS。年龄较大与被诊断为MS的几率较高相关（OR = 1.072；95% CI：1.021 - 1.126），而当前治疗的持续时间较长与几率较低相关（OR = 0.969；95% CI：0.944 - 0.995）；MS及其组成部分在接受康复治疗的PWUD中很普遍。常规筛查和预防措施对于预防代谢综合征至关重要，尤其是在老年人和新接受治疗的人群中。
