A Review of Current Developments in Functionalized Mesoporous Silica Nanoparticles: From Synthesis to Biosensing Applications.

Functionalized mesoporous silica nanoparticles (MSNs) have been widely investigated in the fields of nanotechnology and material science, owing to their high surface area, diverse structure, controllable cavity, high biocompatibility, and ease of surface modification. In the past few years, great efforts have been devoted to preparing functionalized MSNs for biosensing applications with satisfactory performance. The functional structure and composition in the synthesis of MSNs play important roles in high biosensing performance. With the development of material science, diverse functional units have been rationally incorporated into mesoporous structures, which endow MSNs with design flexibility and multifunctionality. Here, an overview of the recent developments of MSNs as nanocarriers is provided, including the methodologies for the preparation of MSNs and the nanostructures and physicochemical properties of MSNs, as well as the latest trends of MSNs and their use in biosensing. Finally, the prospects and challenges of MSNs are presented.