Zhou Jiaojiao, Liu Chen, Zhong Yujun, Luo Zhihui, Wu Long
National R&D Center for Se-Rich Agricultural Products Processing, School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
Biosensors (Basel). 2024 Nov 27;14(12):575. doi: 10.3390/bios14120575.
Functionalized mesoporous silica nanoparticles (MSNs) have been widely investigated in the fields of nanotechnology and material science, owing to their high surface area, diverse structure, controllable cavity, high biocompatibility, and ease of surface modification. In the past few years, great efforts have been devoted to preparing functionalized MSNs for biosensing applications with satisfactory performance. The functional structure and composition in the synthesis of MSNs play important roles in high biosensing performance. With the development of material science, diverse functional units have been rationally incorporated into mesoporous structures, which endow MSNs with design flexibility and multifunctionality. Here, an overview of the recent developments of MSNs as nanocarriers is provided, including the methodologies for the preparation of MSNs and the nanostructures and physicochemical properties of MSNs, as well as the latest trends of MSNs and their use in biosensing. Finally, the prospects and challenges of MSNs are presented.
功能化介孔二氧化硅纳米颗粒（MSNs）因其高比表面积、多样的结构、可控的孔径、高生物相容性以及易于表面修饰等特点，在纳米技术和材料科学领域得到了广泛研究。在过去几年中，人们致力于制备具有令人满意性能的用于生物传感应用的功能化MSNs。MSNs合成中的功能结构和组成在高生物传感性能中起着重要作用。随着材料科学的发展，各种功能单元已被合理地引入介孔结构中，这赋予了MSNs设计灵活性和多功能性。在此，提供了作为纳米载体的MSNs的最新发展概述，包括MSNs的制备方法、MSNs的纳米结构和物理化学性质，以及MSNs的最新趋势及其在生物传感中的应用。最后，介绍了MSNs的前景和挑战。
