Machraoui Safa, Hakmaoui Abdelmalek, Errafii Khaoula, Knidiri Mehdi, Essaadouni Lamiaa, Krati Khadija, Admou Brahim
Laboratory of Immunology and Human Leukocyte Antigen, Center of Clinical Research, Mohammed VI University Hospital, Marrakech 40080, Morocco.
Biosciences Research Laboratory, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech 40080, Morocco.
Curr Issues Mol Biol. 2024 Dec 13;46(12):14080-14094. doi: 10.3390/cimb46120842.
Hepatitis C virus (HCV) infection is one of the major health burdens worldwide. Its course depends on the virus itself and the host's immune responses. The latter are conditioned by immunogenetic factors, in particular human leukocyte antigens (HLAs), whose role in determining the outcome of infection varies according to populations and ethnic groups. The current study attempted to investigate the possible relationship between HLA-A and HLA-B allele polymorphism and its impacts on the clinical outcome of HCV for a better understanding of disease susceptibility and clearance. A cross-sectional and comparative study was carried out on 40 patients with hepatitis C and 100 ethnically matched healthy control subjects originating from southern Morocco. HLA class I alleles were typed using the high-resolution PCR-SSO method. The prevalence of certain HLA class I alleles differed significantly between HCV-infected individuals and healthy controls. In particular, HLA-A02:01 was less prevalent in chronic HCV infection ( = 0.002), indicating a potential protective effect, while the higher prevalence of HLA-A68:02, A66:01 B15:03, B41:02, B44:03, and B*50:01 in patients could indicate a predisposing factor. These findings support the association of these immunogenetic markers with HCV infection, indicating their possible role in determining clinical and genotype forms as well as the outcome of HCV infection. Thus, an in-depth analysis of these alleles could lead to a better understanding of HCV pathogenesis and potential targeted interventions.
丙型肝炎病毒（HCV）感染是全球主要的健康负担之一。其病程取决于病毒本身和宿主的免疫反应。后者受免疫遗传因素的制约，特别是人类白细胞抗原（HLA），其在决定感染结果中的作用因人群和种族而异。本研究试图探讨HLA - A和HLA - B等位基因多态性之间的可能关系及其对HCV临床结局的影响，以便更好地了解疾病易感性和清除情况。对40例来自摩洛哥南部的丙型肝炎患者和100名种族匹配的健康对照者进行了横断面比较研究。采用高分辨率PCR - SSO方法对HLA I类等位基因进行分型。某些HLA I类等位基因的患病率在HCV感染个体和健康对照者之间存在显著差异。特别是，HLA - A02:01在慢性HCV感染中的患病率较低（ = 0.002），表明可能具有保护作用，而患者中HLA - A68:02、A66:01、B15:03、B41:02、B44:03和B*50:01的较高患病率可能表明是一个易感因素。这些发现支持了这些免疫遗传标记与HCV感染的关联，表明它们在决定临床和基因型形式以及HCV感染结局中可能发挥的作用。因此，对这些等位基因进行深入分析可能有助于更好地理解HCV发病机制和潜在的靶向干预措施。
