Faculty of Pharmacy, AIMST University, Jalan Bedong-Semeling, 08100 Bedong, Kedah, Malaysia.
Directorate of Drugs Control Administration, Chennai, India.
Curr Drug Discov Technol. 2020;17(4):507-514. doi: 10.2174/1570163816666190819141344.
About 95% of earth living space lies deep below the ocean's surface and it harbors extraordinary diversity of marine organisms. Marine biodiversity is an exceptional reservoir of natural products, bioactive compounds, nutraceuticals and other potential compounds of commercial value. Timeline for the development of the drug from a plant, synthetic and other alternative sources is too lengthy. Exploration of the marine environment for potential bioactive compounds has gained focus and huge opportunity lies ahead for the exploration of such vast resources in the ocean. Further, the evolution of superbugs with increasing resistance to the currently available drugs is alarming and it needs coordinated efforts to resolve them. World Health Organization recommends the need and necessity to develop effective bioactive compounds to combat problems associated with antimicrobial resistance. Based on these factors, it is imperative to shift the focus towards the marine environment for potential bioactive compounds that could be utilized to tackle antimicrobial resistance. Current research trends also indicate the huge strides in research involving marine environment for drug discovery. The objective of this review article is to provide an overview of marine resources, recently reported research from marine resources, challenges, future research prospects in the marine environment.
约 95%的地球生存空间位于海洋表面以下，这里栖息着非凡多样的海洋生物。海洋生物多样性是天然产物、生物活性化合物、营养保健品和其他具有商业价值的潜在化合物的特殊资源库。从植物、合成物和其他替代物中开发药物的时间线过于漫长。对海洋环境中潜在生物活性化合物的探索已经成为焦点，对海洋中如此巨大资源的探索前景广阔。此外，超级细菌对抗生素的耐药性不断增强，这令人担忧，需要协调努力来解决这些问题。世界卫生组织建议有必要开发有效的生物活性化合物来对抗与抗生素耐药性相关的问题。基于这些因素，必须将重点转向海洋环境，以寻找可能用于解决抗生素耐药性问题的潜在生物活性化合物。目前的研究趋势也表明，在海洋环境中进行药物发现的研究取得了巨大进展。本文的目的是概述海洋资源、最近从海洋资源中报告的研究、挑战以及海洋环境中的未来研究前景。
