Kim Tae-Eun, Kim Do Young, Kim Hyeongsu, Kim Sung Hea
Department of Clinical Pharmacology, Konkuk University Medical Center, Seoul 05030, Republic of Korea.
Division of Cardiology, Department of Internal Medicine, Ajou University Hospital, Ajou School of Medicine, Suwon 16499, Republic of Korea.
Metabolites. 2024 Nov 25;14(12):653. doi: 10.3390/metabo14120653.
Metabolic syndrome (MetS), a cluster of metabolic dysregulations, is recognized as a significant risk factor for the development of heart failure (HF). The pathophysiological mechanisms linking MetS to HF are complex and multifaceted, with the components of MetS contributing to cardiac deterioration through impaired myocardial energy metabolism, increased inflammation, and endothelial dysfunction. Numerous clinical studies have confirmed the relationship between MetS and HF. Multiple studies have demonstrated that the impact of MetS on HF varies by sex and age. Metabolic disorders, including MetS, have a greater impact on HF incidence in younger adults compared to the elderly population and in women compared to men. Although the reasons for these differences are not yet fully understood, recognizing the sex- and age-related variations is crucial for developing targeted strategies to prevent HF in individuals with MetS. Future research should continue to investigate the underlying mechanisms behind these variations and identify optimal management approaches that account for both sex and age in reducing HF risk.
代谢综合征（MetS）是一组代谢失调，被认为是心力衰竭（HF）发生的重要危险因素。将MetS与HF联系起来的病理生理机制复杂且多方面，MetS的各个组成部分通过受损的心肌能量代谢、炎症增加和内皮功能障碍导致心脏恶化。众多临床研究证实了MetS与HF之间的关系。多项研究表明，MetS对HF的影响因性别和年龄而异。与老年人群相比，包括MetS在内的代谢紊乱对年轻成年人的HF发病率影响更大；与男性相比，对女性的影响更大。尽管这些差异的原因尚未完全了解，但认识到与性别和年龄相关的差异对于制定有针对性的策略以预防MetS患者发生HF至关重要。未来的研究应继续调查这些差异背后的潜在机制，并确定在降低HF风险方面兼顾性别和年龄的最佳管理方法。
