Akdaşçi Emir, Eker Furkan, Duman Hatice, Singh Priyanka, Bechelany Mikhael, Karav Sercan
Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Çanakkale 17100, Türkiye.
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
Nanomaterials (Basel). 2024 Dec 16;14(24):2018. doi: 10.3390/nano14242018.
Nanoparticles (NPs) have emerged as a potent choice for various applications, from drug delivery to agricultural studies, serving as an alternative and promising methodology for future advancements. They have been widely explored in delivery systems, demonstrating immense promise and high efficiency for the delivery of numerous biomolecules such as proteins and anticancer agents, either solely or modified with other compounds to enhance their capabilities. In addition, the utilization of NPs extends to antimicrobial studies, where they are used to develop novel antibacterial, antifungal, and antiviral formulations with advanced characteristics. Lactoferrin (Lf) is a glycoprotein recognized for its significant multifunctional properties, such as antimicrobial, antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Its activity has a broad distribution in the human body, with Lf receptors present in multiple regions. Current research shows that Lf is utilized in NP technology as a surface material, encapsulated biomolecule, and even as an NP itself. Due to the abundance of Lf receptors in various regions, Lf can be employed as a surface material in NPs for targeted delivery strategies, particularly in crossing the BBB and targeting specific cancers. Furthermore, Lf can be synthesized in an NP structure, positioning it as a strong candidate in future NP-related applications. In this article, we explore the highlighted and underexplored areas of Lf applications in NPs research.
纳米颗粒（NPs）已成为从药物递送到农业研究等各种应用的有力选择，是未来进步的一种替代且有前景的方法。它们在递送系统中得到了广泛探索，在递送众多生物分子（如蛋白质和抗癌剂）方面展现出巨大的潜力和高效率，这些生物分子既可以单独使用，也可以与其他化合物结合进行修饰以增强其性能。此外，纳米颗粒的应用还扩展到抗菌研究领域，用于开发具有先进特性的新型抗菌、抗真菌和抗病毒制剂。乳铁蛋白（Lf）是一种糖蛋白，因其具有抗菌、抗氧化、抗炎、抗癌和神经保护等显著的多功能特性而闻名。其活性在人体中分布广泛，Lf受体存在于多个区域。目前的研究表明，Lf在纳米颗粒技术中可用作表面材料、封装生物分子，甚至本身就是一种纳米颗粒。由于Lf受体在各个区域的丰富存在，Lf可用作纳米颗粒的表面材料用于靶向递送策略，特别是在穿越血脑屏障和靶向特定癌症方面。此外，Lf可以以纳米颗粒结构合成，使其成为未来与纳米颗粒相关应用的有力候选者。在本文中，我们探讨了Lf在纳米颗粒研究中的应用中已被突出和未被充分探索的领域。
