Eker Furkan, Duman Hatice, Akdaşçi Emir, Witkowska Anna Maria, Bechelany Mikhael, Karav Sercan
Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Çanakkale 17100, Türkiye.
Department of Food Biotechnology, Medical University of Bialystok, 15-089 Bialystok, Poland.
Nanomaterials (Basel). 2024 Oct 10;14(20):1618. doi: 10.3390/nano14201618.
Silver nanoparticles (NPs) have become highly promising agents in the field of biomedical science, offering wide therapeutic potential due to their unique physicochemical properties. The unique characteristics of silver NPs, such as their higher surface-area-to-volume ratio, make them ideal for a variety of biological applications. They are easily processed thanks to their large surface area, strong surface plasmon resonance (SPR), stable nature, and multifunctionality. With an emphasis on the mechanisms of action, efficacy, and prospective advantages of silver NPs, this review attempts to give a thorough overview of the numerous biological applications of these particles. The utilization of silver NPs in diagnostics, such as bioimaging and biosensing, as well as their functions in therapeutic interventions such as antimicrobial therapies, cancer therapy, diabetes treatment, bone repair, and wound healing, are investigated. The underlying processes by which silver NPs exercise their effects, such as oxidative stress induction, apoptosis, and microbial cell membrane rupture, are explored. Furthermore, toxicological concerns and regulatory issues are discussed, as well as the present difficulties and restrictions related to the application of silver NPs in medicine.
银纳米颗粒(NPs)已成为生物医学科学领域极具前景的试剂,因其独特的物理化学性质而具有广泛的治疗潜力。银纳米颗粒的独特特性,如较高的表面积与体积比,使其适用于各种生物应用。由于其大表面积、强表面等离子体共振(SPR)、稳定的性质和多功能性,它们易于加工。本文着重于银纳米颗粒的作用机制、功效和潜在优势,试图全面概述这些颗粒的众多生物应用。研究了银纳米颗粒在诊断(如生物成像和生物传感)中的应用,以及它们在抗菌治疗、癌症治疗、糖尿病治疗、骨修复和伤口愈合等治疗干预中的作用。探讨了银纳米颗粒发挥作用的潜在过程,如氧化应激诱导、细胞凋亡和微生物细胞膜破裂。此外,还讨论了毒理学问题和监管问题,以及目前银纳米颗粒在医学应用中存在的困难和限制。