Cau Riccardo, Pisu Francesco, Montisci Roberta, D'Angelo Tommaso, Mantini Cesare, Salgado Rodrigo, Saba Luca
Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari-Polo di Monserrato s.s. 554 Monserrato, 09045 Cagliari, Italy.
Department of Cardiology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari-Polo di Monserrato s.s. 554 Monserrato, 09045 Cagliari, Italy.
Tomography. 2024 Nov 27;10(12):1881-1894. doi: 10.3390/tomography10120137.
The purpose of this study was to explore the impact of pericardial T1 mapping as a potential supportive non-contrast cardiovascular magnetic resonance (CMR) parameter in the diagnosis of acute pericarditis. Additionally, we investigated the relationship between T1 mapping values in acute pericarditis patients and their demographic data, cardiovascular risk factors, clinical parameters, cardiac biomarkers, and cardiac function.
This retrospective study included CMR scans in 35 consecutive patients with acute pericarditis (26 males, 45.54 ± 23.38 years). Moreover, we included 17 sex- and age-matched healthy controls (12 males, mean age 47.78 ±19.38 years). CMR-derived pericardial T1 mapping values, which included all pericardial structures within the pericardial layers-encompassing both pericardial effusion and pericardial layer thickness-were analyzed and compared between acute pericarditis patients and controls.
Compared to the matched control group, acute pericarditis patients demonstrated significantly lower pericardial T1 mapping values (2137 ms ± 519 vs. 3268 ms ± 362, = 0.001). In the multivariable analysis, the pericardial T1 mapping value was independently associated with the severity of pericardial late gadolinium enhancement (LGE) (β coefficient = -3.271, = 0.003). The receiver operating characteristic curve analysis showed that the diagnostic performance of pericardial T1 mapping in discriminating acute pericarditis patients was excellent, with an area under the curve of 0.97 (95% CI = 0.94-0.98), using a threshold of 2862.5 ms.
Pericardial T1 mapping values could serve as an additional non-contrast CMR parameter for identifying patients with acute pericarditis, demonstrating an independent association with the severity of pericardial LGE.
本研究旨在探讨心包T1映射作为一种潜在的支持性非对比心血管磁共振（CMR）参数在急性心包炎诊断中的作用。此外，我们还研究了急性心包炎患者的T1映射值与其人口统计学数据、心血管危险因素、临床参数、心脏生物标志物和心脏功能之间的关系。
这项回顾性研究纳入了35例连续的急性心包炎患者（26例男性，年龄45.54±23.38岁）的CMR扫描。此外，我们还纳入了17例性别和年龄匹配的健康对照者（12例男性，平均年龄47.78±19.38岁）。分析并比较了急性心包炎患者和对照组之间CMR衍生的心包T1映射值，该值包括心包层内的所有心包结构，涵盖心包积液和心包层厚度。
与匹配的对照组相比，急性心包炎患者的心包T1映射值显著更低（2137 ms±519 vs. 3268 ms±362，P = 0.001）。在多变量分析中，心包T1映射值与心包延迟钆增强（LGE）的严重程度独立相关（β系数 = -3.271，P = 0.003）。受试者工作特征曲线分析表明，心包T1映射在鉴别急性心包炎患者方面的诊断性能优异，曲线下面积为0.97（95%CI = 0.94 - 0.98），使用的阈值为2862.5 ms。
心包T1映射值可作为识别急性心包炎患者的额外非对比CMR参数，与心包LGE的严重程度存在独立关联。
