Thalén Simon, Ramos Joao G, Engblom Henrik, Sigfridsson Andreas, Sörensson Peder, Ugander Martin
Department of Clinical Physiology, Karolinska Institute, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden.
Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Eur Heart J Imaging Methods Pract. 2023 Sep 19;1(2):qyad028. doi: 10.1093/ehjimp/qyad028. eCollection 2023 Sep.
T mapping cardiovascular magnetic resonance (CMR) imaging has been used to characterize pericardial effusions. The aim of this study was to measure pericardial fluid native T values in healthy volunteers to establish normal values.
Prospectively recruited volunteers ( = 30) underwent CMR at 1.5 T, and native T maps were acquired using a modified look-locker inversion recovery 5s(3s)3s acquisition scheme. A volume of pericardial fluid was imaged in a short-axis slice and in a slice perpendicular to the short-axis orientation. A reliable measurement had a region of interest (ROI) size > 10 mm, coefficient of variation < 10%, and a relative difference < 5% between the two slice orientations. In 26/30 (87%) of volunteers, there was a sufficient amount of pericardial fluid to enable reliable measurement. Native T of pericardial fluid was 3262 ± 163 (95% normal limits 2943-3581 ms) and did not differ in the perpendicular slice orientation (3267 ± 173 ms, = 0.75), due to sex (female 3311 ± 177 vs. male 3220 ± 142 ms, = 0.17), age ( = 0.03, = 0.44), heart rate ( = 0.005, = 0.7), or size of the ROI (0.06, = 0.23).
This study shows that T values can be reliably measured in the pericardial fluid of healthy volunteers. It is the first to report normal reference ranges for T values at 1.5 T in the pericardial fluid of healthy volunteers.
T 映射心血管磁共振（CMR）成像已用于表征心包积液。本研究的目的是测量健康志愿者的心包液固有 T 值以确定正常值。
前瞻性招募的志愿者（n = 30）在 1.5 T 下接受 CMR 检查，并使用改良的 Look-Locker 反转恢复 5s(3s)3s 采集方案获取固有 T 图。在心尖短轴切片和垂直于短轴方向的切片中对心包液体积进行成像。可靠测量的感兴趣区域（ROI）大小 > 10 mm，变异系数 < 10%，且两个切片方向之间的相对差异 < 5%。在 26/30（87%）的志愿者中，有足够量的心包液以进行可靠测量。心包液的固有 T 值为 3262 ± 163（95%正常范围 2943 - 3581 ms），在垂直切片方向上无差异（3267 ± 173 ms，P = 0.75），不受性别（女性 3311 ± 177 与男性 3220 ± 142 ms，P = 0.17）、年龄（P = 0.03，r = 0.44）、心率（P = 0.005，r = 0.7）或 ROI 大小（P = 0.06，r = 0.23）影响。
本研究表明，健康志愿者心包液中的 T 值可可靠测量。这是首次报告健康志愿者心包液在 1.5 T 时 T 值的正常参考范围。
