Wang Yandong, Chang Fei, Li Yutang, Wang Fenglong, Li Can, Li Hui, Jiang Yanyan
Key Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan, Shandong, 250061, PR China.
Department of Oral and Maxillofacial Surgery, The Second Hospital of Shandong University, Jinan, Shandong, 250033, PR China.
Biomaterials. 2025 Jun;317:123046. doi: 10.1016/j.biomaterials.2024.123046. Epub 2024 Dec 24.
Chronic diabetic wound poses a pressing global healthcare challenge, necessitating an approach to address issues such as pathogenic bacteria elimination, blood sugar regulation, and angiogenesis stimulation. Herein, we engineered a BiWO@CuO-GOx bio-heterojunction (BWCG bio-HJ) with exceptional cascade catalytic performance and impressive sonosensitivity to remodel the wound microenvironment and expedite the diabetic wound healing. Specifically, the Z-scheme junctions of BiWO@CuO significantly augmented carrier separation dynamics, leading to the highly efficient generation of reactive oxygen species (ROS) upon US irradiations. Furthermore, glucose oxidase (GOx) grafted on the BiWO@CuO surface facilitated the conversion of glucose into HO and glucuronic acid, providing a rich supply for Cu-mediated Fenton-like reactions. The robust oxidation effect disrupted the bacteria's phosphotransferase system (PTS), hindering glucose uptake, glycolysis, and energy metabolism, ultimately inducing bacterial death and reshaping the diabetic wound microenvironment. The BWCG bio-HJ was formulated as an antibacterial spray for chronic diabetic wound repair. Extensive in vitro and in vivo experiments confirmed that the BWCG bio-HJ spray could eliminate pathogenic bacteria, consume local blood sugar, and promote angiogenesis, collagen deposition, and epithelialization, thereby accelerating the diabetic wound healing process. This bio-heterojunction spray comprehensively addressed the principal pathological factors associated with diabetic wounds, offering a promising strategy for combatting stubborn infections.
慢性糖尿病伤口给全球医疗保健带来了紧迫挑战，需要一种方法来解决诸如消除病原菌、调节血糖和刺激血管生成等问题。在此，我们设计了一种具有卓越级联催化性能和令人印象深刻的声敏性的BiWO@CuO-GOx生物异质结（BWCG生物异质结），以重塑伤口微环境并加速糖尿病伤口愈合。具体而言，BiWO@CuO的Z型结显著增强了载流子分离动力学，导致在超声辐照下高效产生活性氧（ROS）。此外，接枝在BiWO@CuO表面的葡萄糖氧化酶（GOx）促进了葡萄糖向H₂O和葡萄糖醛酸的转化，为铜介导的类芬顿反应提供了丰富的反应物。强大的氧化作用破坏了细菌的磷酸转移酶系统（PTS），阻碍了葡萄糖摄取、糖酵解和能量代谢，最终导致细菌死亡并重塑糖尿病伤口微环境。BWCG生物异质结被制成用于慢性糖尿病伤口修复的抗菌喷雾剂。广泛的体外和体内实验证实，BWCG生物异质结喷雾剂可以消除病原菌、消耗局部血糖，并促进血管生成、胶原蛋白沉积和上皮形成，从而加速糖尿病伤口愈合过程。这种生物异质结喷雾剂全面解决了与糖尿病伤口相关的主要病理因素，为对抗顽固性感染提供了一种有前景的策略。
