Lerner E M, Stone S H, Myers R E
J Neuroimmunol. 1985 Feb-Mar;7(5-6):299-313.
Severe (24/24) and lethal (22/24) autoimmune encephalomyelitis was regularly induced in rhesus monkeys of all age groups from newborns to adults by a single injection of guinea pig spinal cord in complete Freund's adjuvant. Age dependency of the encephalomyelitis was manifested by a delayed onset and prolonged course in newborn monkeys. A hemorrhagic retinopathy usually accompanying the earliest CNS symptoms was observed in most of these monkeys. The most severe lesions were predominant in the cerebellum and brainstem of neonates, and in the cerebral hemispheres of older animals.
通过单次注射完全弗氏佐剂中的豚鼠脊髓，在从新生猴到成年猴的所有年龄组恒河猴中均可定期诱发严重（24/24）和致死性（22/24）自身免疫性脑脊髓炎。新生猴的脑脊髓炎存在年龄依赖性，表现为发病延迟和病程延长。在大多数这些猴子中观察到一种通常伴随最早中枢神经系统症状的出血性视网膜病变。最严重的病变在新生儿的小脑和脑干以及年长动物的大脑半球中占主导。
