Christadoss P, Lindstrom J, Munro S, Talal N
J Neuroimmunol. 1985 Apr;8(1):29-41. doi: 10.1016/s0165-5728(85)80045-x.
An extensive analysis of the relationship between immunological parameters and clinical responses and biochemical loss of muscle acetylcholine receptors (AChR) was performed in murine experimental autoimmune myasthenia gravis. The onset of clinical muscle weakness correlated strongly with the onset of significant muscle AChR loss. Mice with clinical muscle weakness had greater amount of muscle AChR loss. There was no correlation between the concentration of anti-AChR antibodies and the presence of clinical muscle weakness or amount of muscle AChR loss. However, the kinetics of autoantibody response correlated well with that of muscle AChR loss.
在小鼠实验性自身免疫性重症肌无力中，对免疫参数与临床反应以及肌肉乙酰胆碱受体（AChR）生化损失之间的关系进行了广泛分析。临床肌肉无力的发作与显著的肌肉AChR损失的发作密切相关。出现临床肌肉无力的小鼠肌肉AChR损失量更大。抗AChR抗体的浓度与临床肌肉无力的存在或肌肉AChR损失量之间没有相关性。然而，自身抗体反应的动力学与肌肉AChR损失的动力学密切相关。
