Prostakishina E A, Sidenko E A, Kolegova E S, Patysheva M R, Kononova G A, Choinzonov E L
Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Laboratory of Tumor Biochemistry, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Int J Oral Maxillofac Surg. 2025 Jun;54(6):479-493. doi: 10.1016/j.ijom.2024.12.006. Epub 2024 Dec 26.
Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer. The development and progression of OSCC are closely linked to various aetiological factors. Early signs of OSCC may manifest as oral lesions, genetic abnormalities, and chronic inflammation. Lesions with dysplastic features have a high risk of malignant transformation into OSCC. Moreover, dysplastic lesions are characteristic of many oral potentially malignant disorders (OPMDs). Currently, there is no unified standard of treatment for OPMD patients, due to the variability in risk factors and mechanisms of transformation. Therefore, it is essential to detect and manage OPMDs at an early stage in order to prevent their malignant transformation into OSCC. This necessitates analysing OPMD mechanisms to identify objective markers for predicting the risk of malignant transformation. The aim of this review was to describe the process of OPMD transformation into OSCC under the influence of environmental, immune, microbiome, and molecular factors.
口腔鳞状细胞癌（OSCC）是头颈部最常见的癌症类型。OSCC的发生和发展与多种病因密切相关。OSCC的早期症状可能表现为口腔病变、基因异常和慢性炎症。具有发育异常特征的病变具有转化为OSCC的高风险。此外，发育异常病变是许多口腔潜在恶性疾病（OPMD）的特征。目前，由于风险因素和转化机制的变异性，OPMD患者尚无统一的治疗标准。因此，早期检测和管理OPMD对于预防其恶性转化为OSCC至关重要。这就需要分析OPMD机制以识别预测恶性转化风险的客观标志物。本综述的目的是描述在环境、免疫、微生物群和分子因素影响下OPMD转化为OSCC的过程。
