Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia.
Int J Mol Sci. 2020 Feb 11;21(4):1197. doi: 10.3390/ijms21041197.
Extracellular vesicles (EVs) are secreted from most cell types and utilized in a complex network of near and distant cell-to-cell communication. Insight into this complex nanoscopic interaction in the development, progression and treatment of oral squamous cell carcinoma (OSCC) and precancerous oral mucosal disorders, termed oral potentially malignant disorders (OPMDs), remains of interest. In this review, we comprehensively present the current state of knowledge of EVs in OSCC and OPMDs. A systematic literature search strategy was developed and updated to December 17, 2019. Fifty-five articles were identified addressing EVs in OSCC and OPMDs with all but two articles published from 2015, highlighting the novelty of this research area. Themes included the impact of OSCC-derived EVs on phenotypic changes, lymph-angiogenesis, stromal immune response, mechanisms of therapeutic resistance as well as utility of EVs for drug delivery in OSCC and OPMD. Interest and progress of knowledge of EVs in OSCC and OPMD has been expanding on several fronts. The oral cavity presents a unique and accessible microenvironment for nanoparticle study that could present important models for other solid tumours.
细胞外囊泡 (EVs) 由大多数细胞类型分泌，并在近程和远程细胞间通讯的复杂网络中发挥作用。在口腔鳞状细胞癌 (OSCC) 和癌前口腔黏膜疾病（称为口腔潜在恶性疾病，OPMDs）的发展、进展和治疗中，对这种复杂的纳米级相互作用的深入了解仍然很有意义。在这篇综述中，我们全面介绍了 EVs 在 OSCC 和 OPMDs 中的最新研究进展。我们制定并更新了系统的文献搜索策略，截止到 2019 年 12 月 17 日，共确定了 55 篇探讨 EVs 在 OSCC 和 OPMDs 中的应用的文章，其中只有两篇文章发表于 2015 年之前，这突显了该研究领域的新颖性。主题包括 OSCC 衍生的 EVs 对表型改变、淋巴血管生成、基质免疫反应、治疗耐药机制以及在 OSCC 和 OPMD 中应用 EVs 进行药物递送的影响。对 EVs 在 OSCC 和 OPMD 中的研究兴趣和知识进展已经在多个方面展开。口腔为纳米颗粒研究提供了一个独特且易于进入的微环境，可能为其他实体瘤提供重要的模型。
