Faggioni Giovanni, Moramarco Filippo, Luciano Emiliana, De Santis Riccardo, Amoroso Alessandra, Petralito Giancarlo, Molinari Filippo, Grosso Paolo, Rozov Orr, Morelli Diego, Carbone Daniele, Lista Florigio
Defence Institute for Biomedical Sciences, 00184, Rome, Italy.
Italian Department of Defence, 00184, Rome, Italy.
Sci Rep. 2024 Dec 28;14(1):30665. doi: 10.1038/s41598-024-78381-8.
The clinical manifestations of SARS-CoV-2 infection may range from asymptomatic or minor conditions to severe and life-threatening outcomes. The respiratory system is a principal target of the virus and in the majority of cases of severe disease, an acute form of pneumonia develops. Despite concerted global efforts to elucidate the pathogenic mechanisms of COVID-19, the progression of the infection leading to pulmonary damage remains poorly understood. The present study aimed to analyse the immunological profile of subjects with a previous SARS-CoV-2 infection and predisposition to lung injury. The results showed a strong correlation between IgG anti-membrane antibodies and lung injury.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的临床表现可能从无症状或轻微症状到严重及危及生命的后果不等。呼吸系统是该病毒的主要靶标，在大多数严重疾病病例中，会发展为急性肺炎。尽管全球共同努力阐明2019冠状病毒病（COVID-19）的致病机制，但导致肺损伤的感染进展仍知之甚少。本研究旨在分析既往有SARS-CoV-2感染且易发生肺损伤的受试者的免疫特征。结果显示，抗膜IgG抗体与肺损伤之间存在密切相关性。
