Rashid Abdurazak, Ejara Daba, Deybasso Haji Aman
School of Public Health and Medicine, Adama General Hospital and Medical College, Adama, Ethiopia.
School of Nursing, Madda Walabu University, Shashamene Campus, Shashamene, Ethiopia.
Sci Rep. 2024 Dec 28;14(1):30712. doi: 10.1038/s41598-024-80086-x.
Interventions designed to improve medication adherence, and blood pressure control have not been effective globally. There is limited comprehensive understanding regarding the level of drug adherence to antihypertensive medications in Ethiopia, particularly in the study area. This study aimed to assess adherence to antihypertensive medication and associated factors among patients with hypertension on follow-up at public health facilities of Adama town, Oromia, Ethiopia. A multicenter cross-sectional study was conducted among 402 patients with hypertension from January 1 to February 30, 2022. The objectives of the study were explained to participants in the local language and written informed consent was obtained. The level of adherence was measured by Morisky Medication Adherence Scale. Data were entered into Epidata and exported to Statistical Package for the Social Science for analysis. Bivariable and multivariable logistic regression analyses were conducted to determine associations between independent variables and medication adherence. Adjusted Odds ratios with 95% confidence interval were estimated to assess the strength of associations. Statistical significance was declared at a P-value < 0.05. The proportion of adherence to antihypertensive medication was 63.4% (95% CI: 59.1-66.9). Respondents under the age of 49 years ( (AOR = 2.3, 95% CI: 1.009-5.459), ages 49-59 years (AOR = 3.2, 95% CI: 1.452-7.396), and ages 60-71 years (AOR = 2.7,95% CI: 1.207-6.066), who were married (AOR = 2.1, 95% CI: 1.056-4.19), urban residents (AOR = 3.9, 95% CI: 1.486-10.949), and patients with a monthly income between 5500 and 8249 Ethiopian Birr (AOR = 4.150, CI: 1.083-15.097) were more likely to be adherent to antihypertensive medications. : The adherence to the antihypertensive drug in this study was lower compared to the expected index, 80%. Education and counseling should focus on older age, rural residents, single, and patients with higher monthly incomes.
旨在提高药物依从性和血压控制的干预措施在全球范围内并不有效。关于埃塞俄比亚抗高血压药物的依从水平，特别是在研究区域，人们的全面了解有限。本研究旨在评估埃塞俄比亚奥罗米亚州阿达马镇公共卫生机构接受随访的高血压患者对抗高血压药物的依从性及相关因素。2022年1月1日至2月28日，对402例高血压患者进行了多中心横断面研究。研究目的用当地语言向参与者解释，并获得了书面知情同意书。依从水平通过莫利斯基药物依从性量表进行测量。数据录入Epidata并导出到社会科学统计软件包进行分析。进行了双变量和多变量逻辑回归分析，以确定自变量与药物依从性之间的关联。估计了调整后的比值比及95%置信区间，以评估关联强度。P值<0.05时具有统计学意义。抗高血压药物的依从率为63.4%（95%CI：59.1-66.9）。年龄在49岁以下（调整后比值比=2.3，95%CI：1.009-5.459）、49-59岁（调整后比值比=3.2，95%CI：1.452-7.396）、60-71岁（调整后比值比=2.7，95%CI：1.207-6.066）的受访者，已婚者（调整后比值比=2.1，95%CI：1.056-4.19）、城市居民（调整后比值比=3.9，95%CI：1.486-10.949）以及月收入在5500至8249埃塞俄比亚比尔之间的患者（调整后比值比=4.150，CI：1.083-15.097）更有可能坚持服用抗高血压药物。本研究中抗高血压药物的依从性低于预期指标80%。教育和咨询应关注老年人、农村居民、单身者以及月收入较高的患者。
