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用于预测儿童支原体肺炎的列线图模型的构建与验证

Construction and validation of a nomogram model to predict bronchiolitis Mycoplasma pneumoniae pneumonia in children.

作者信息

Xiong Shuping, Lin Lihua, Chen Qihong, Peng Jie, Yang Yungang

机构信息

Department of Pediatrics, Pediatric Key Laboratory of Xiamen, the First Affiliated Hospital of Xiamen University, Xiamen, 361003, China.

The School of Clinical Medicine, Fujian Medical University, Fuzhou, China.

出版信息

Sci Rep. 2024 Dec 28;14(1):30758. doi: 10.1038/s41598-024-80906-0.

Abstract

After the cancellation of COVID-19 epidemic control measures in 2023, cases of pediatric bronchiolitis caused by Mycoplasma pneumoniae (MP) have been reported successively, with some children experiencing residual bronchiolitis obliterans (BO). Currently, the diagnosis of bronchiolitis Mycoplasma pneumoniae pneumonia (MPP) primarily relies on high-resolution computed tomography (HRCT). To establish a predictive model for bronchiolitis MPP, a retrospective analysis was conducted. The patients were randomly divided into a training cohort and a validation cohort. The nomogram model was constructed in the training cohort. Finally, the differential, calibration, and clinical applicability of the prediction model were evaluated using both the training and validation cohorts. Logistic stepwise regression analysis identified age, atopy, wheezing, hypoxemia, and pleural effusion as independent predictors of bronchiolitis MPP. These factors were used to construct a nomogram model. This nomogram model serves as a useful tool for predicting the risk of bronchiolitis MPP, which may facilitate individualized early intervention.

摘要

2023年新型冠状病毒肺炎疫情防控措施取消后,陆续报告了由肺炎支原体(MP)引起的小儿细支气管炎病例,部分患儿出现了闭塞性细支气管炎(BO)。目前,肺炎支原体肺炎(MPP)合并细支气管炎的诊断主要依靠高分辨率计算机断层扫描(HRCT)。为建立MPP合并细支气管炎的预测模型,进行了一项回顾性分析。将患者随机分为训练队列和验证队列。在训练队列中构建列线图模型。最后,使用训练队列和验证队列评估预测模型的鉴别、校准和临床适用性。逻辑逐步回归分析确定年龄、特应性、喘息、低氧血症和胸腔积液为MPP合并细支气管炎的独立预测因素。这些因素被用于构建列线图模型。该列线图模型是预测MPP合并细支气管炎风险的有用工具,可能有助于个体化早期干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5d0/11681095/86ac862e1e83/41598_2024_80906_Fig1_HTML.jpg

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