Lv Yan-Tian, Sun Xiao-Jing, Chen Ying, Ruan Ting, Xu Guo-Peng, Huang Jian-An
Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Respiratory and Critical Medicine, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Ann Transl Med. 2022 Oct;10(20):1123. doi: 10.21037/atm-22-4304.
) is a common pathogen of respiratory tract infections, but there is still a lack of detailed investigation on the large sample of infection in the all age population. And patients with severe pneumonia (SMPP) still have a certain risk of death. How to identify the clinical characteristics and population of patients with SMPP as soon as possible is still an urgent problem in clinical practice.
Demographic characteristics, patient clinical information, and laboratory data of 81,131 patients with respiratory tract infections (RTIs) in the Affiliated Suzhou Hospital of Nanjing Medical University from 2014 to 2020 were retrospectively collected from all patient records. The serum particle agglutination (PA) test was used to determine infection by detecting specific antibodies. The white blood cell count, the proportion of neutrophils and lymphocytes, C-reactive protein (CRP) and lactate dehydrogenase (LDH) levels between children and adults with SMPP were compared by Student's -test; other clinical features were analyzed by χ test or Fisher's exact test.
A total of 81,131 patients with RTIs were included, and 21,582 (26.60%) immunoglobulin M (IgM)-positive patients were detected. From 2014 to 2020, the annual proportions of RTIs were 23.60%, 28.18%, 38.08%, 27.05%, 23.44%, 25.26%, and 18.33%, respectively. In terms of seasonal distribution, April-June and September-November were the peak seasons of infection each year. Children and women have a high proportion of infection. The peak age of infection was between 4 and 14 years old. There were 301 cases of SMPP, including 281 children and 20 adults (8 cases of pregnant women). Children and pregnant women accounted for a high proportion of SMPP. Children with SMPP had more extrapulmonary symptoms, multilobar infiltrates, and increased CRP and LDH levels compared with adults.
infection has seasonal, sex, and age distribution trends. Children and pregnant women accounted for a high proportion of SMPP. Extrapulmonary symptoms, multilobar infiltrates, and increased CRP and LDH levels may be helpful to identify SMPP in children than in adults.
（病原体名称未给出）是呼吸道感染的常见病原体，但对于全年龄人群中该病原体感染的大样本仍缺乏详细研究。而且重症（病原体名称未给出）肺炎（SMPP）患者仍有一定死亡风险。如何尽快识别SMPP患者的临床特征及人群仍是临床实践中的紧迫问题。
回顾性收集2014年至2020年南京医科大学附属苏州医院81131例呼吸道感染（RTIs）患者的人口统计学特征、患者临床信息及实验室数据。采用血清颗粒凝集（PA）试验通过检测特异性抗体来确定（病原体名称未给出）感染。采用Student's t检验比较儿童和成人SMPP患者的白细胞计数、中性粒细胞和淋巴细胞比例、C反应蛋白（CRP）及乳酸脱氢酶（LDH）水平；其他临床特征采用χ检验或Fisher精确检验进行分析。
共纳入81131例RTIs患者，检测到21582例（26.60%）免疫球蛋白M（IgM）阳性患者。2014年至2020年，（病原体名称未给出）RTIs的年占比分别为23.60%、28.18%、38.08%、27.05%、23.44%、25.26%和18.33%。在季节分布方面，每年4月至6月和9月至11月是（病原体名称未给出）感染的高峰季节。儿童和女性（病原体名称未给出）感染比例较高。（病原体名称未给出）感染的高峰年龄在4至14岁。有301例SMPP患者，其中儿童281例，成人20例（孕妇8例）。儿童和孕妇在SMPP中占比高。与成人相比，儿童SMPP患者有更多肺外症状、多叶浸润，且CRP和LDH水平升高。
（病原体名称未给出）感染具有季节、性别和年龄分布趋势。儿童和孕妇在SMPP中占比高。肺外症状、多叶浸润以及CRP和LDH水平升高可能有助于在儿童中比在成人中更准确地识别SMPP。
