Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
J Immunol Res. 2022 Jun 26;2022:9227838. doi: 10.1155/2022/9227838. eCollection 2022.
Mycoplasma pneumoniae is a common pathogen of community-acquired pneumonia (CAP) in children. infection is usually regarded as a self-limiting disease, but in some special cases, it can also develop into refractory Mycoplasma pneumoniae pneumonia (RMPP). The aim of this study is to analyze the clinical characteristics of CRP (C-reactive protein), LDH (lactate dehydrogenase), ESR (erythrocyte sedimentation rate), , neutrophils (%), lymphocytes (%), and lung consolidation in RMPP and explore their prediction results in the early stage of RMPP, which is important for early treatment.
This systematic search was conducted in PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wangfang, and Cqvip, and the date was set until February 23, 2021. For the continuous variables, mean difference (MD) with 95% CI was adopted to evaluate CRP, LDH, ESR, D-dimer, neutrophils (%), lymphocytes (%), and the correlation between lung consolidation and RMPP.
20 studies including 5289 patients were included in the analysis, and the results showed that the CRP of the RMPP group (MD (95% CI): 22.29 (12.20, 32.38), < 0.001), LDH (MD (95% CI): 145.13 (78.62, 211.64), < 0.001), neutrophils (%) (MD (95% CI): 7.27 (0.31, 14.23), = 0.04), and D-dimer (MD (95% CI): 1.79 (-1.17, 4.74), = 0.24) was higher than that of the NRMPP group; the risk of lung consolidation in the RMPP group (OR (95% CI): 14.29 (4.52, 45.12), < 0.001) was higher than that in the NRMPP group, and there was no difference in ESR (MD (95% CI): 8.11 (-1.34, 17.56), = 0.09) and lymphocytes (%) (MD (95% CI): -6.27 (-12.81, 0.27), = 0.06) between the two groups.
So, the available evidence indicates that CRP, LDH, neutrophils (%), , and lung consolidation are predictive factors for RMPP.
肺炎支原体是儿童社区获得性肺炎（CAP）的常见病原体。感染通常被认为是自限性疾病，但在某些特殊情况下，也可发展为难治性肺炎支原体肺炎（RMPP）。本研究旨在分析 C 反应蛋白（CRP）、乳酸脱氢酶（LDH）、红细胞沉降率（ESR）、、中性粒细胞（%）、淋巴细胞（%）和肺实变在 RMPP 中的临床特征，并探讨其在 RMPP 早期的预测结果，这对于早期治疗非常重要。
系统检索 PubMed、Embase、Cochrane 图书馆、Web of Science、CNKI、万方、维普数据库，检索时间截至 2021 年 2 月 23 日。对于连续性变量，采用均数差（MD）及其 95%置信区间（CI）评估 CRP、LDH、ESR、D-二聚体、中性粒细胞（%）、淋巴细胞（%）和肺实变与 RMPP 的相关性。
共纳入 20 项研究 5289 例患者，结果显示 RMPP 组 CRP[MD（95%CI）：22.29（12.20，32.38）]、LDH[MD（95%CI）：145.13（78.62，211.64）]、中性粒细胞（%）[MD（95%CI）：7.27（0.31，14.23）]、D-二聚体[MD（95%CI）：1.79（-1.17，4.74）]高于非 RMPP 组；RMPP 组肺实变的风险[OR（95%CI）：14.29（4.52，45.12）]高于非 RMPP 组，ESR[MD（95%CI）：8.11（-1.34，17.56）]和淋巴细胞（%）[MD（95%CI）：-6.27（-12.81，0.27）]两组间差异无统计学意义。
现有证据表明，CRP、LDH、中性粒细胞（%）、、肺实变是 RMPP 的预测因素。
