Hutson S W, Cowen P N, Bird C C
J Clin Pathol. 1985 Mar;38(3):281-7. doi: 10.1136/jcp.38.3.281.
Ageing changes in the normal human female breast were studied to determine their significance for the evolution of mammary cancer. Employing the morphometric techniques of point counting and planimetry, objective quantitative measurements were made of the structure of the normal female breast in 58 subjects from the prepubertal to late postreproductive period. The relative amounts of epithelial and connective tissue varied with age, and the epithelial elements (combined lobular and extralobular) were unevenly distributed within the gland, with lower containing more than upper quadrants. The upper outer quadrant, however, usually contained the largest proportion of lobular units, which may relate to the higher incidence of lobular carcinoma found in this quadrant. Involution was shown to be a premenopausal rather than postmenopausal phenomenon. Mammary dysplastic changes were uncommon in all age groups.
研究了正常女性乳房的衰老变化，以确定其对乳腺癌演变的意义。采用点计数和平面测量的形态计量技术，对58名从青春期前到生殖后期的正常女性乳房结构进行了客观定量测量。上皮组织和结缔组织的相对含量随年龄变化，上皮成分（小叶和小叶外成分合并）在腺体内分布不均，下象限比上象限含量更多。然而，外上象限通常含有最大比例的小叶单位，这可能与该象限小叶癌发病率较高有关。结果表明， involution是绝经前而非绝经后的现象。乳腺发育异常变化在所有年龄组中都不常见。
