一名造血干细胞移植受者的棘阿米巴感染：诊断、管理及感染源鉴定中的挑战
Acanthamoeba Infection in a Hematopoietic Cell Transplant Recipient: Challenges in Diagnosis, Management, and Source Identification.
作者信息
Banerjee Camellia T, Conlan Sean, Mostaghim Anahita, Michelin Angela, Arduino Matthew, Mattioli Mia, Haston Julia C, Das Sanchita, Seyedmousavi Amir, Chang Bickey H, O'Connell Elise M, Kanakry Christopher G, Dilara Akbulut, Quezado Martha, Gea-Banacloche Juan, Deming Clay, Segre Julia A, Han Alison, Cuellar-Rodriguez Jennifer
机构信息
Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Microbial Genomics Section, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
出版信息
Transpl Infect Dis. 2025 Jan-Feb;27(1):e14425. doi: 10.1111/tid.14425. Epub 2024 Dec 28.
We report a case of Acanthamoeba infection in an HCT recipient with steroid-refractory GVHD. We highlight the multiple challenges that free-living ameba infections present to the clinician, the clinical laboratory, transplant infectious disease for review, hospital epidemiology if nosocomial transmission is considered, and public health officials, as exposure source identification can be a significant challenge. Transplant physicians should include Acanthamoeba infections in their differential diagnosis of a patient with skin, sinus, lung, and/or brain involvement.
我们报告了一例造血干细胞移植（HCT）受者发生棘阿米巴感染且患有类固醇难治性移植物抗宿主病（GVHD）的病例。我们强调了自由生活阿米巴感染给临床医生、临床实验室、负责会诊的移植传染病专家、若考虑医院内传播则还有医院流行病学专家以及公共卫生官员带来的多重挑战，因为确定暴露源可能是一项重大挑战。移植医生应将棘阿米巴感染纳入对有皮肤、鼻窦、肺部和/或脑部受累患者的鉴别诊断中。
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