Maes Michael, Jirakran Ketsupar, Vasupanrajit Asara, Zhou Bo, Tunvirachaisakul Chavit, Stoyanov Drozdstoj St, Almulla Abbas F
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, 610072, China.
Neuro Endocrinol Lett. 2024 Dec 10;45(6):393-408.
Severe or recurring major depression is associated with increased adverse childhood experiences (ACEs), heightened atherogenicity, and immune-linked neurotoxicity (INT). Nevertheless, the interconnections among these variables in outpatient major depression (OMDD) have yet to be determined. We aim to determine the correlations among INT, atherogenicity, and ACEs in OMDD patients compared to normal controls.
This study includes 66 OMDD patients (of whom 33 had metabolic syndrome, MetS) and 67 controls (31 of whom had MetS) and used Multiplex Immunoassay to assess serum levels of forty eight cytokines/chemokines/growth factors.
The free cholesterol/reverse cholesterol transport ratio, apolipoprotein (Apo) B and E, and a comprehensive atherogenicity index were all significantly associated with increased INT in subjects without MetS. ACEs were substantially correlated with INT in individuals with MetS. INT (only in MetS) and atherogenicity indices (only in people without MetS) were significantly associated with the clinical phenome features of OMDD, including the recurrence of illness (ROI, including lifetime suicidal behaviors), the lifetime phenome (neuroticism, lifetime anxiety disorders and dysthymia), and the current phenome (including current suicidal behaviors). A significant proportion of the variability (58.3%) in the lifetime + current phenome could be accounted for by INT, interactions between INT and atherogenicity (labeled "atherommune index"), ApoE, three ACE subtypes (all positively correlated), and age (inversely correlated). A common latent construct could be extracted from ROI, lifetime phenome, current phenome, INT, and atherommune index. 36.1% of this factor's variance was accounted for by three ACE subtypes.
We have developed a novel OMDD model, namely a pathway phenotype, labeled the "atherommune-phenome," which demonstrates that the interplay between INT and atherogenicity is essential to OMDD.
重度或复发性重度抑郁症与童年不良经历（ACEs）增加、动脉粥样硬化性增强以及免疫相关神经毒性（INT）有关。然而，门诊重度抑郁症（OMDD）中这些变量之间的相互联系尚未确定。我们旨在确定与正常对照组相比，OMDD患者中INT、动脉粥样硬化性和ACEs之间的相关性。
本研究纳入66例OMDD患者（其中33例患有代谢综合征，MetS）和67例对照者（其中31例患有MetS），并使用多重免疫测定法评估48种细胞因子/趋化因子/生长因子的血清水平。
在没有MetS的受试者中，游离胆固醇/逆向胆固醇转运比率、载脂蛋白（Apo）B和E以及综合动脉粥样硬化指数均与INT增加显著相关。在患有MetS的个体中，ACEs与INT显著相关。INT（仅在MetS中）和动脉粥样硬化指数（仅在没有MetS的人群中）与OMDD的临床表型特征显著相关，包括疾病复发（ROI，包括终生自杀行为）、终生表型（神经质、终生焦虑症和心境恶劣）以及当前表型（包括当前自杀行为）。INT、INT与动脉粥样硬化性之间的相互作用（标记为“动脉免疫指数”）、ApoE、三种ACE亚型（均呈正相关）和年龄（呈负相关）可解释终生 + 当前表型中很大一部分变异性（58.3%）。可以从ROI、终生表型、当前表型、INT和动脉免疫指数中提取一个共同的潜在结构。该因子变异的36.1%由三种ACE亚型解释。
我们开发了一种新的OMDD模型，即一种途径表型，标记为“动脉免疫 - 表型”，它表明INT与动脉粥样硬化性之间的相互作用对OMDD至关重要。
