Dunbar Karen J, Efe Gizem, Cunningham Katherine, Esquea Emily, Navaridas Raul, Rustgi Anil K
Herbert Irving Comprehensive Cancer Center, New York, NY, 10032, USA.
Herbert Irving Comprehensive Cancer Center, New York, NY, 10032, USA; Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Trends Cancer. 2025 Mar;11(3):216-231. doi: 10.1016/j.trecan.2024.11.012. Epub 2024 Dec 27.
Metastasis is responsible for most cancer-related deaths. Different cancers have their own preferential sites of metastases, a phenomenon termed metastatic organotropism. The mechanisms underlying organotropism are multifactorial and include the generation of a pre-metastatic niche (PMN), metastatic homing, colonization, dormancy, and metastatic outgrowth. Historically, studies of metastatic organotropism have been limited by a lack of models allowing direct comparison of cells exhibiting different patterns of tropism. However, new innovative models and large-scale sequencing efforts have propelled organotropism research. Herein, we summarize the recent discoveries in metastatic organotropism regulation, focusing on lung, liver, brain, and bone tropism. We discuss how emerging technologies are continuing to improve our ability to model and, hopefully, predict and treat organotropism.
转移是导致大多数癌症相关死亡的原因。不同的癌症有其各自偏好的转移部位，这一现象被称为转移嗜器官性。转移嗜器官性的潜在机制是多因素的，包括前转移微环境（PMN）的形成、转移归巢、定植、休眠和转移灶生长。从历史上看，转移嗜器官性的研究一直受到缺乏模型的限制，这些模型无法直接比较表现出不同嗜性模式的细胞。然而，新的创新模型和大规模测序工作推动了嗜器官性研究。在此，我们总结了转移嗜器官性调控方面的最新发现，重点关注肺、肝、脑和骨嗜性。我们讨论了新兴技术如何持续提高我们对嗜器官性进行建模的能力，以及有望预测和治疗嗜器官性的能力。
