利用代谢活性聚合物纳米颗粒构建免疫机制
Engineering immunity using metabolically active polymeric nanoparticles.
作者信息
Griffin Kate V, Saunders Michael N, Lyssiotis Costas A, Shea Lonnie D
机构信息
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
出版信息
Trends Biotechnol. 2025 Jun;43(6):1371-1384. doi: 10.1016/j.tibtech.2024.11.016. Epub 2024 Dec 27.
Immune system functions play crucial roles in both health and disease, and these functions are regulated by their metabolic programming. The field of immune engineering has emerged to develop therapeutic strategies, including polymeric nanoparticles (NPs), that can direct immune cell phenotype and function by directing immunometabolic changes. Precise control of bioenergetic processes may offer the opportunity to prevent undesired immune activity and improve disease-specific outcomes. In this review we discuss the role that polymeric NPs can play in shaping immunometabolism and subsequent immune system activity through particle-mediated delivery of metabolically active agents as either structural components or cargo.
免疫系统功能在健康和疾病中都起着至关重要的作用，并且这些功能由其代谢程序调控。免疫工程领域已经兴起，旨在开发治疗策略，包括聚合物纳米颗粒（NPs），其可以通过引导免疫代谢变化来指导免疫细胞表型和功能。对生物能量过程的精确控制可能提供预防不良免疫活动并改善疾病特异性结果的机会。在这篇综述中，我们讨论了聚合物纳米颗粒通过颗粒介导的代谢活性剂递送作为结构成分或货物在塑造免疫代谢及随后的免疫系统活性中所起的作用。
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