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精英女性重度压力性尿失禁运动员治疗策略的无监督聚类分析:聚焦于恢复比赛和改善压力性尿失禁

Unsupervised clustering analysis of treatment strategies for elite female athletes with severe stress urinary incontinence: focusing on competition return and SUI improvement.

作者信息

Okui Nobuo, Okui Machiko

机构信息

Yokosuka Urogynecology and Urology Clinic, Ootaki 2-6, Yokosuka, Kanagawa, 238-0008, Japan.

出版信息

Int Urol Nephrol. 2025 May;57(5):1493-1501. doi: 10.1007/s11255-024-04337-6. Epub 2024 Dec 29.

Abstract

PURPOSE

To evaluate two primary outcomes in elite female athletes (EFAs) with severe stress urinary incontinence (SUI) 24 months post-intervention: return to elite-level competition and improvement in SUI symptoms. Clustering analysis was conducted to identify subgroups within the patient population and explore treatment efficacy.

METHODS

A retrospective analysis was performed on 183 EFAs with severe SUI who underwent treatments including pelvic floor muscle training (PFMT), vaginal and urethral erbium laser (Fotona Laser), and mid-urethral sling (MUS) surgery. Clustering analysis was conducted using K-means to categorize patients, followed by multivariate regression and Random Forest to determine predictors.

RESULTS

Three distinct clusters were identified. PFMT frequency was the most significant predictor of both return to sports and SUI improvement across clusters. Cluster 0, characterized by younger participants, required interventions like MUS surgery and Fotona Laser for significant improvement. Cluster 2, with high PFMT adherence, showed the best improvement in pad test results (4.9 g) and the highest return to sports rate (85.9%). Fotona Laser was particularly effective in Cluster 2, with 91.3% of patients returning to sports within one year. In contrast, Cluster 1, which included older participants with more severe symptoms, demonstrated the least improvement and lowest return to sports rate (2.8%), likely due to lower PFMT frequency and inconsistent training.

CONCLUSION

Clustering analysis effectively categorized EFAs with SUI, highlighting the critical role of personalized, intensive PFMT in achieving sports return and symptom improvement. Future research should validate findings in larger cohorts and integrate machine learning to refine personalized medicine.

摘要

目的

评估精英女性运动员(EFA)在干预24个月后出现严重压力性尿失禁(SUI)的两个主要结果:重返精英水平比赛和SUI症状改善。进行聚类分析以确定患者群体中的亚组并探索治疗效果。

方法

对183名接受包括盆底肌肉训练(PFMT)、阴道和尿道铒激光(Fotona激光)以及中段尿道吊带(MUS)手术等治疗的重度SUI的EFA进行回顾性分析。使用K均值进行聚类分析以对患者进行分类,随后进行多元回归和随机森林分析以确定预测因素。

结果

确定了三个不同的聚类。PFMT频率是所有聚类中重返运动和SUI改善的最显著预测因素。聚类0的特点是参与者较年轻,需要进行MUS手术和Fotona激光等干预措施才能取得显著改善。聚类2对PFMT的依从性高,在护垫试验结果方面改善最佳(4.9克),重返运动率最高(85.9%)。Fotona激光在聚类2中特别有效,91.3%的患者在一年内重返运动。相比之下,聚类1包括症状更严重的老年参与者,改善最少,重返运动率最低(2.8%),这可能是由于PFMT频率较低和训练不一致所致。

结论

聚类分析有效地对患有SUI的EFA进行了分类,突出了个性化、强化PFMT在实现运动恢复和症状改善方面的关键作用。未来的研究应在更大的队列中验证研究结果,并整合机器学习以完善个性化医疗。

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