Wihandani Desak Made, Dewi Wiryanthini Ida Ayu, Yani Made Violin Weda, Indrani Remitha Ni Putu Sri, Stiti Sadvika I Gusti Ayu, Indrakusuma Anak Agung Bagus Putra, Anda Tusta Adiputra Putu, Supadmanaba I Gede Putu
Biochemistry Department, Faculty of Medicine, Udayana University, Bali, Indonesia.
Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia.
Asian Pac J Cancer Prev. 2024 Dec 1;25(12):4175-4180. doi: 10.31557/APJCP.2024.25.12.4175.
This study aimed to determine the expression of CD44 in breast cancer and its association with patients' clinicopathological data, particularly in Bali.
This was a cross-sectional study in the Integrated Biomedical Laboratory and Biochemistry Laboratory of the Faculty of Medicine Udayana University, during January-December 2022, which lasted 12 months with 46 samples.
The study showed that the age range of our subjects was 38-86 years old, with the majority of the parity being less than three. The mean CD44 expression in all samples was 1177.83 ± 268.47 ng/mL. Based on the clinicopathological data, there was a significant difference in CD44 expression based on the patient's menstrual status (p=0.016), tumor size (p=0.003), and stage (p=0.002). Based on the analysis using the chi-square test with a cut-off CD44 expression of 85.81, significant results (p=0.001) were obtained on the association of CD44 expression with tumor size. The cut-off value with the stage of breast cancer was 99.66 and showed a significant association between CD44 expression advanced stage (p = 0.001) in breast cancer patients. Other variables showed insignificant results.
CD44 protein expression in breast cancer patients is between 35.47-1407.83 ng/mL. This study showed a significant association between CD44 expression with tumor size and the advanced stage of breast cancer patients.
本研究旨在确定CD44在乳腺癌中的表达及其与患者临床病理数据的关联，特别是在巴厘岛地区。
这是一项于2022年1月至12月在乌达亚纳大学医学院综合生物医学实验室和生物化学实验室进行的横断面研究；该研究持续了12个月，共采集了46个样本。
研究表明，我们研究对象的年龄范围为38至86岁，大多数人的胎次小于3次。所有样本中CD44的平均表达量为1177.83±268.47 ng/mL。基于临床病理数据，CD44的表达在患者月经状态（p=0.016）、肿瘤大小（p=0.003）和分期（p=0.002）方面存在显著差异。基于卡方检验分析，以CD44表达截断值85.81进行分析，得出CD44表达与肿瘤大小之间存在显著关联（p=0.001）。乳腺癌分期的截断值为99.66，且显示CD44表达与乳腺癌患者晚期之间存在显著关联（p = 0.001）。其他变量显示结果不显著。
乳腺癌患者中CD44蛋白表达在35.47-1407.83 ng/mL之间。本研究表明CD44表达与肿瘤大小及乳腺癌患者晚期之间存在显著关联。
