Risk Factors for Death from Heart Disease in Elderly Colon Cancer Patients with Liver Metastasis.

BACKGROUND

Colon cancer is one of the most frequently diagnosed cancers worldwide. The study aimed to identify the risk factors of death from heart disease in the elderly colon cancer patients with liver metastasis.

METHODS

All data of the retrospective study were retrieved from database of the Surveillance, Epidemiology, and End Results between 2000 and 2020. Odds ratio (OR) and the corresponding 95% confidence intervals (CIs) were calculated by using logistic regression model.

RESULTS

A total of 14322 elderly colon cancer patients with liver metastasis were identified. Out of them, 288 cases died of heart diseases, and 2001 cases were alive. In multivariate logistic analysis, the significant predictors for heart disease death were old age (OR = 1.06, p = 0.000), other histologic type besides adenocarcinoma (OR = 1.68, p = 0.004) and tumor size ≥ 5cm (OR = 1.89, p = 0.000). The protective factors were metastases besides liver (OR = 0.70, p = 0.027), surgery (OR = 0.64, p = 0.001) and chemotherapy (OR = 0.23, p = 0.000).

CONCLUSION

Among elderly colon cancer with liver metastases, it is crucial to identify the risk factors and adopt preventive methods and appropriate treatment, which may enhance the quality of patient care and prolong patients' survival.