年龄相关性脑萎缩：一项计算机断层扫描研究

Age-related brain atrophy: a study with computed tomography.

作者信息

Takeda S, Matsuzawa T

出版信息

J Gerontol. 1985 Mar;40(2):159-63. doi: 10.1093/geronj/40.2.159.

DOI:10.1093/geronj/40.2.159

Abstract

Brain atrophy in 176 men and 205 women without neurologic disturbances was studied using x-ray computed tomography. The ages ranged from 21 to 79 years. We measured cerebrospinal fluid (CSF) space volume above the level of the tentorium cerebelli and calculated brain atrophy index (BAI): BAI (%) = (CSF space volume/cranial cavity volume). Both the CSF space volume and BAI decreased from the 20s to the 30s only in men (p less than .001), and both were minimal in the 30s in men and in the 20s in women. Although both the CSF space volume and BAI started to increase in the 40s in both sexes (p less than .001, .002), considerable atrophy of the brain started to occur in the 40s in men and in the 50s in women. Both the CSF space volume and BAI increased exponentially with age after the 30s in both sexes (p less than .001).

摘要

利用X射线计算机断层扫描技术，对176名男性和205名无神经功能障碍的女性的脑萎缩情况进行了研究。年龄范围在21岁至79岁之间。我们测量了小脑幕水平以上的脑脊液（CSF）空间容积，并计算了脑萎缩指数（BAI）：BAI（%）=（CSF空间容积/颅腔容积）。仅在男性中，CSF空间容积和BAI在20多岁到30多岁期间有所下降（p<0.001），且在男性30多岁和女性20多岁时两者均为最低。尽管CSF空间容积和BAI在40多岁时在两性中均开始增加（p<0.001，0.002），但男性在40多岁时以及女性在50多岁时开始出现明显的脑萎缩。在30多岁之后，两性的CSF空间容积和BAI均随年龄呈指数增长（p<0.001）。