Hatazawa J, Ito M, Yamaura H, Matsuzawa T
J Am Geriatr Soc. 1982 Apr;30(4):235-9. doi: 10.1111/j.1532-5415.1982.tb07092.x.
Brain atrophy in 154 men and 147 women without neurologic deficits was quantitatively studied by means of computed tomography. The ages ranged from 20 to 79 years. The volume percentage of brain to cranial cavity (Craniocerebral Index, or CCI) was calculated by means of computer programs available in CT systems. The mean CCI in the 20-39 age group was constant at 98.4 per cent in men and 98.7 in women, and this was considered the standard for the CCI in subjects with nonatrophied brains. The percentage of each subject's CCI in relation to this standard in both sexes (Brain Volume Index, or BVI) was calculated as the indicator of brain atrophy. The normal value for BVI was therefore 100 per cent in both sexes. A clear difference was observed between men and women in the process of brain atrophy with increasing age. In men a significant reduction in BVI began in the sixth decade of life (P less than 0.01); thereafter, the decline was gradual and steady through the eighth decade (P less than 0.05). In women, a significant reduction in BVI began in the fifth decade (P less than 0.01) and remained relatively constant during the fifth and sixth decades but declined significantly again in the seventh and eighth decades. In both sexes, remarkable individual differences in brain atrophy were characteristic.
采用计算机断层扫描技术对154名男性和147名无神经功能缺损的女性的脑萎缩情况进行了定量研究。年龄范围为20至79岁。通过CT系统中可用的计算机程序计算脑体积占颅腔的体积百分比（颅脑指数，即CCI）。20至39岁年龄组男性的平均CCI为98.4%，女性为98.7%，这被视为脑未萎缩受试者的CCI标准。计算每个受试者的CCI相对于该标准的百分比（脑体积指数，即BVI），作为脑萎缩的指标。因此，男女BVI的正常值均为100%。随着年龄增长，在脑萎缩过程中观察到男女之间存在明显差异。男性在60岁时BVI开始显著下降（P<0.01）；此后，在80岁之前下降逐渐且稳定（P<0.05）。女性在50岁时BVI开始显著下降（P<0.01），在50岁和60岁时相对稳定，但在70岁和80岁时再次显著下降。在男女两性中，脑萎缩存在显著的个体差异是其特点。
