新加坡儿童脐带血中全氟烷基物质浓度与自闭症特征的关联：新加坡健康成长研究
Associations of cord blood concentrations of perfluoroalkyl substances with autistic traits in Singaporean children: The growing up in Singapore towards healthy outcomes study.
作者信息
Mascari Michael, Cohen Nathan, Yao Meizhen, Huang Jonathan, Lane Jamil, Reeves Katherine W, Balasubramanian Raji, Liu Zhenhua, Laouali Nasser, Daniel Lourdes Mary, Chen Chia-Yang, Seng Chong Yap, Shiao-Yng Chan, Kee Michelle Z L, Valvi Damaskini, Oulhote Youssef
机构信息
Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts at Amherst, 715 North Pleasant Street, Amherst, MA, 01003, USA.
Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY, 10029, USA.
出版信息
Chemosphere. 2025 Feb;371:144040. doi: 10.1016/j.chemosphere.2024.144040. Epub 2025 Jan 8.
BACKGROUND
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social deficits and repetitive behaviors. Environmental pollutants may contribute to the etiology of ASD, but studies of perfluoroalkyl substances (PFAS) have shown conflicting results.
OBJECTIVES
We assessed associations between cord blood concentrations of PFAS with autistic traits at age seven years in a Singaporean birth cohort.
METHODS
We measured cord blood concentrations of eight PFAS in a sample of 430 mother-child pairs from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort. We assessed autistic traits using the Social Responsiveness Scale Second Edition (SRS-2) and its sub-scores, in which higher scores indicate more autistic traits. We estimated covariate-adjusted associations between the PFAS and SRS-2 scores using Bayesian weighted quantile sum (BWQS) regression models for the PFAS mixtures and multivariable regressions for single PFAS. We additionally evaluated effect modification by biological sex.
RESULTS
We observed a positive association between the PFAS mixture and SRS-2 cognition sub-scores (β per SD increase = 1.25 points, 95% CI -0.03, 2.40). Perfluorononanoic acid (PFNA) was the strongest contributor to the mixture effect. In single PFAS models, exposure to PFNA was associated with a higher SRS-2 total score (β = 0.93 points, 95% CI 0.29, 1.58), cognition sub-score (β = 1.26 points, 95% CI 0.55, 1.97), communication sub-score (β = 0.88 points, 95% CI 0.20, 1.56), and restrictive and repetitive behaviors sub-score (β = 0.93 points, 95% CI 0.23, 1.63). We also observed evidence of effect modification by sex for perfluoroundecanoic acid (PFUnDA) for the total score (p-effect modification [EM] = 0.03), cognition sub-score (p-EM = 0.03), and communication sub-score (p-EM = 0.04), with negative associations seen in females and null associations in males.
DISCUSSION
Cord blood PFAS concentrations were positively associated with autistic traits measured by SRS-2.
背景
自闭症谱系障碍（ASD）是一种神经发育障碍，其特征为社交缺陷和重复行为。环境污染物可能在ASD的病因中起作用，但关于全氟烷基物质（PFAS）的研究结果相互矛盾。
目的
我们评估了新加坡出生队列中七岁儿童脐带血PFAS浓度与自闭症特征之间的关联。
方法
我们在来自“新加坡成长迈向健康结果”（GUSTO）队列的430对母婴样本中测量了八种PFAS的脐带血浓度。我们使用第二版社会反应量表（SRS-2）及其子分数评估自闭症特征，分数越高表明自闭症特征越明显。我们使用贝叶斯加权分位数和（BWQS）回归模型估计PFAS混合物与SRS-2分数之间的协变量调整关联，对于单一PFAS则使用多变量回归。我们还评估了生物学性别的效应修饰作用。
结果
我们观察到PFAS混合物与SRS-2认知子分数之间呈正相关（每标准差增加β = 1.25分，95%置信区间 -0.03，2.40）。全氟壬酸（PFNA）是混合物效应的最强贡献者。在单一PFAS模型中，暴露于PFNA与较高的SRS-2总分（β = 0.93分，95%置信区间0.29，1.58）、认知子分数（β = 1.26分，95%置信区间0.55，1.97）、沟通子分数（β = 0.88分，95%置信区间0.20，1.56）以及限制性和重复行为子分数（β = 0.93分，95%置信区间0.23，1.63）相关。我们还观察到全氟十一烷酸（PFUnDA）在总分（p-效应修饰[EM] = 0.03）、认知子分数（p-EM = 0.03）和沟通子分数（p-EM = 0.04）方面存在性别效应修饰的证据，女性中呈负相关，男性中无关联。
讨论
脐带血PFAS浓度与通过SRS-2测量的自闭症特征呈正相关。
Zotero 插件