Manzano-Salgado Cyntia B, Casas Maribel, Lopez-Espinosa Maria-Jose, Ballester Ferran, Iñiguez Carmen, Martinez David, Romaguera Dora, Fernández-Barrés Silvia, Santa-Marina Loreto, Basterretxea Mikel, Schettgen Thomas, Valvi Damaskini, Vioque Jesus, Sunyer Jordi, Vrijheid Martine
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL) , Barcelona, Spain.
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) , Madrid, Spain.
Environ Health Perspect. 2017 Sep 20;125(9):097018. doi: 10.1289/EHP1330.
Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce and inconsistent.
We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM-risk score.
We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester). We assessed weight gain from birth until 6 mo. At 4 and 7 y, we calculated the age- and sex-specific -scores for BMI, waist circumference (WC), and blood pressure (BP) (n≈1,000). At age 4, we calculated the age-, sex-, and region-specific -scores for cholesterol, triglycerides (TGs), high-density (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (n=627). At age 4, we calculated a CM-risk score (n=386) as the sum of the individual age-, sex-, and region-specific -scores for WC, BP, HDL-C, and TGs. We used the average between the negative of HDL-C -score and TGs -score to give similar weight to lipids and the other components in the score. A higher score indicates a higher cardiometabolic risk at age 4.
PFOS and PFOA were the most abundant PFAS (geometric mean: 5.80 and 2.32 ng/mL, respectively). In general, prenatal PFAS concentrations were not associated with individual outcomes or the combined CM-risk score. Exceptions were positive associations between prenatal PFHxS and TGs -score [for a doubling of exposure, β=0.11; 95% confidence interval (CI): 0.01, 0.21], and between PFNA and the CM-risk score (β=0.60; 95% CI: 0.04, 1.16). There was not clear or consistent evidence of modification by sex.
We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. https://doi.org/10.1289/EHP1330.
全氟烷基物质（PFAS）可能会影响儿童时期的体重指数（BMI）以及心脏代谢（CM）风险的其他组成部分，但相关证据稀少且不一致。
我们估计了产前PFAS暴露与心脏代谢风险相关结局之间的关联，包括综合CM风险评分。
我们测量了孕妇血浆（孕早期）中的全氟己烷磺酸（PFHxS）、全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）和全氟壬酸（PFNA）。我们评估了从出生到6个月的体重增加情况。在4岁和7岁时，我们计算了BMI、腰围（WC）和血压（BP）的年龄和性别特异性z评分（n≈1000）。在4岁时，我们计算了胆固醇、甘油三酯（TGs）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）的年龄、性别和地区特异性z评分（n = 627）。在4岁时，我们计算了一个CM风险评分（n = 386），该评分是WC、BP、HDL-C和TGs的个体年龄、性别和地区特异性z评分之和。我们使用HDL-C z评分的负值与TGs z评分的平均值，以使脂质和评分中的其他成分具有相似的权重。较高的评分表明4岁时心脏代谢风险较高。
PFOS和PFOA是最丰富的PFAS（几何平均值分别为5.80和2.32 ng/mL）。一般来说，产前PFAS浓度与个体结局或综合CM风险评分无关。例外情况是产前PFHxS与TGs z评分之间存在正相关[暴露增加一倍，β = 0.11；95%置信区间（CI）：0.01，0.21]，以及PFNA与CM风险评分之间存在正相关（β = 0.60；95%CI：0.04，1.16）。没有明确或一致的证据表明存在性别差异。
在一组从出生到7岁的西班牙儿童队列中，我们观察到几乎没有证据表明低产前PFAS暴露与心脏代谢风险相关结局之间存在关联。https://doi.org/10.1289/EHP1330
Zotero 插件