Chai Min, Zhang Chun-Yan, Chen Shuai, Xu Da-Hai
Department of Emergency Medicine, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China.
Department of Rehabilitation Medicine, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China.
World J Stem Cells. 2024 Dec 26;16(12):990-1001. doi: 10.4252/wjsc.v16.i12.990.
In this editorial, we have taken an in-depth look at the article published by Wan . The study showed that preconditioning mesenchymal stem cells (MSCs) protected them against programmed cell death, and increased their survival rate and therapeutic potential. Autophagy, a type of programmed cell death, is a major intracellular degradation and recycling pathway that is crucial for maintaining cellular homeostasis, self-renewal, and pluripotency. We have explored the relationship between autophagy and MSCs to determine the role of autophagy in the therapeutic applications of MSCs.
在这篇社论中，我们深入研究了万发表的文章。该研究表明，对间充质干细胞（MSCs）进行预处理可保护它们免受程序性细胞死亡的影响，并提高其存活率和治疗潜力。自噬是一种程序性细胞死亡，是细胞内主要的降解和再循环途径，对于维持细胞内稳态、自我更新和多能性至关重要。我们探讨了自噬与间充质干细胞之间的关系，以确定自噬在间充质干细胞治疗应用中的作用。
