Liu Xin-Chen, Lu Jin-Jin, Chen Yu-Meng, Qiu Ying, Zheng Meng-Dan, Wang Zi-Lin, Li Xiang-Wei
Dept. of Endodontics, Jilin University Hospital of Stomatology, Changchun 130021, China;Jilin Province Key Laboratory of Dental Development and Jaw Remodeling and Regeneration, Changchun 130021, China.
Jilin Province Key Laboratory of Dental Development and Jaw Remodeling and Regeneration, Changchun 130021, China;Dept. of Pediatric Dentistry, Jilin University Hospital of Stomatology, Changchun 130021, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Dec 1;38(6):704-707. doi: 10.7518/hxkq.2020.06.017.
Mesenchymal stem cells (MSCs), which have the potential of self-replication and differentiation, are a very valuable cell source for stem cell-based medical therapy. Their application has opened up a new way for disease research. Although MSCs can maintain cell stemness through self-renewal, with the prolongation of cell passage and culture time, the stemness of MSCs gradually decays, and the cell aging and differentiation potential decreases gradually. Autophagy is a highly conserved cytological process that degrades the modified, excess, and deleterious cytoplasmic components in autophagosomes, which are then degraded by fusion with lysosomes. As the main intracellular degradation and recycling pathway, autophagy plays an active role in maintaining cell homeostasis, self-renewal and pluripotency. In this paper, the role of autophagy in self-renewal and maintenance of multidirectional differentiation potential of MSCs was reviewed, which laid a theoretical foundation and practical basis for the research and application of MSCs.
间充质干细胞（MSCs）具有自我复制和分化的潜力，是基于干细胞的医学治疗中非常有价值的细胞来源。它们的应用为疾病研究开辟了一条新途径。虽然MSCs可以通过自我更新维持细胞干性，但随着细胞传代和培养时间的延长，MSCs的干性逐渐衰退，细胞衰老和分化潜能逐渐降低。自噬是一种高度保守的细胞学过程，它降解自噬体中修饰的、多余的和有害的细胞质成分，然后通过与溶酶体融合将其降解。作为主要的细胞内降解和再循环途径，自噬在维持细胞稳态、自我更新和多能性方面发挥着积极作用。本文综述了自噬在MSCs自我更新和维持多向分化潜能中的作用，为MSCs的研究和应用奠定了理论基础和实践基础。
