Wei Yanan, Zheng Zejun, Zhang Ying, Sun Jinmeng, Xu Shuangshuang, Di Xinsheng, Ding Xiaoling, Ding Gang
School of Stomatology, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Clinical Competency Training Center, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Open Med (Wars). 2024 May 21;19(1):20240968. doi: 10.1515/med-2024-0968. eCollection 2024.
Autophagy, a process that isolates intracellular components and fuses them with lysosomes for degradation, plays an important cytoprotective role by eliminating harmful intracellular substances and maintaining cellular homeostasis. Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the capacity for self-renewal that can give rise to a subset of tissues and therefore have potential in regenerative medicine. However, a variety of variables influence the biological activity of MSCs following their proliferation and transplantation . The regulation of autophagy in MSCs represents a possible mechanism that influences MSC differentiation properties under the right microenvironment, affecting their regenerative and therapeutic potential. However, a deeper understanding of exactly how autophagy is mobilized to function as well as clarifying the mechanisms by which autophagy promotes MSCs differentiation is still needed. Here, we review the current literature on the complex link between MSCs differentiation and autophagy induced by various extracellular or intracellular stimuli and the molecular targets that influence MSCs lineage determination, which may highlight the potential regulation of autophagy on MSCs' therapeutic capacity, and provide a broader perspective on the clinical application of MSCs in the treatment of a wide range of diseases.
自噬是一个将细胞内成分分离并与溶酶体融合以进行降解的过程，它通过清除有害的细胞内物质和维持细胞内稳态发挥重要的细胞保护作用。间充质干细胞（MSCs）是具有自我更新能力的多能祖细胞，能够分化为多种组织，因此在再生医学中具有潜力。然而，多种变量会影响MSCs增殖和移植后的生物学活性。MSCs中自噬的调节是一种可能的机制，在合适的微环境下影响MSCs的分化特性，进而影响其再生和治疗潜力。然而，仍需要更深入地了解自噬究竟是如何被调动发挥作用的，以及阐明自噬促进MSCs分化的机制。在此，我们综述了当前关于MSCs分化与各种细胞外或细胞内刺激诱导的自噬之间复杂联系的文献，以及影响MSCs谱系确定的分子靶点，这可能会突出自噬对MSCs治疗能力的潜在调节作用，并为MSCs在治疗多种疾病中的临床应用提供更广阔的视角。
