Kotre Colin John
Institute of Health, University of Cumbria, Bowerham Road, Lancaster, LA1 3JD, United Kingdom.
BJR Open. 2024 Dec 18;7(1):tzae043. doi: 10.1093/bjro/tzae043. eCollection 2025 Jan.
To establish a link between radiation dosimetry and disability-adjusted life-years (DALY) with the aim of quantifying the justification of medical exposures.
The health detriment, defined as lifetime loss of DALY at age of exposure to ionizing radiation for a US-European population was calculated. A simple model of the relationship was fitted to the results. Apart from in late life within the latency period for radiation-induced cancers, most of the relationship can be adequately fitted to a straight line of negative gradient. The gradient of this line corresponds to a loss of DALY per year following exposure to radiation and is therefore equivalent to a disability weight (DW) used in the calculation of DALY.
Radiation dose-dependent DWs for radiation exposure to a US-European population are estimated as 0.020 DALY/yr/Sv for males and 0.022 DALY/yr/Sv for females.
By comparing a range of 66 radiological examinations in terms of the DWs of the disease or injury states with the DWs resulting from the associated radiological exposures, it is demonstrated graphically that the resulting benefit is far greater than the detriment in every case.
The definition of a DW for ionizing radiation, proportional to effective dose as currently defined, can link radiation exposure to the existing large body of data on the DALY burden and DWs for a wide range of diseases and injuries, providing a means for the quantitative justification of the benefit-detriment balance of medical exposures.
建立辐射剂量学与伤残调整生命年（DALY）之间的联系，以量化医疗照射的合理性。
计算了健康损害，即针对欧美人群在暴露于电离辐射时的年龄所导致的终生DALY损失。将一个简单的关系模型拟合到结果中。除了在辐射诱发癌症的潜伏期后期，大部分关系都可以很好地拟合到一条负斜率的直线上。这条直线的斜率对应于辐射暴露后每年的DALY损失，因此等同于计算DALY时使用的伤残权重（DW）。
针对欧美人群，辐射暴露的辐射剂量依赖性DW估计为男性0.020 DALY/年/希沃特，女性0.022 DALY/年/希沃特。
通过将66项放射学检查在疾病或损伤状态的DW与相关放射学暴露所导致的DW进行比较，以图形方式表明，在每种情况下所获得的益处远大于损害。
电离辐射DW的定义与当前定义的有效剂量成比例，可将辐射暴露与关于DALY负担和多种疾病及损伤的DW的现有大量数据联系起来，为定量证明医疗照射的利弊平衡提供了一种方法。
