Goldblum S E, Reed W P
J Lab Clin Med. 1985 Mar;105(3):374-9.
We studied whether pneumococcal (PNC) sonicate-induced leukostasis is specific for the lung or whether it occurs in extrapulmonary foci as well. Indium 111-radiolabeled rabbit granulocytes were infused into rabbits that were then challenged with nonviable PNC or normal saline solution. Animals were killed at either 3 or 24 hours after infusion and washed tissue sections from lung, liver, spleen, brain, heart, and kidney were weighed. Tissue 111In radioactivities from each PNC sonicate-challenged animal were compared with those from a control simultaneously injected with saline solution. At both 3 and 24 hours after injection, 111In radioactivity was significantly (p less than 0.01) increased in the lungs of animals challenged with PNC compared with controls injected with saline solution. There were no significant differences between experimental and control animals in liver, spleen, heart, kidney, or brain radioactivities. Animals in another group were injected with PNC through catheters placed in either the right atrium or left ventricle. Significantly (p less than 0.03) increased 111In radioactivity was found after either route of administration only in the lung.
我们研究了肺炎球菌（PNC）超声裂解物诱导的白细胞停滞是否是肺部特有的，还是也会发生在肺外病灶。将铟111放射性标记的兔粒细胞注入兔子体内，然后用灭活的PNC或生理盐水对其进行攻击。在注入后3小时或24小时处死动物，并对来自肺、肝、脾、脑、心脏和肾脏的冲洗组织切片进行称重。将每只接受PNC超声裂解物攻击的动物的组织铟111放射性与同时注射生理盐水的对照动物的组织铟111放射性进行比较。在注射后3小时和24小时，与注射生理盐水的对照动物相比，接受PNC攻击的动物肺部的铟111放射性显著增加（p<0.01）。在肝、脾、心脏、肾脏或脑放射性方面，实验动物和对照动物之间没有显著差异。另一组动物通过置于右心房或左心室的导管注射PNC。仅在肺部，两种给药途径后均发现铟111放射性显著增加（p<0.03）。
