Vega G L, Beltz W F, Grundy S M
J Lipid Res. 1985 Jan;26(1):115-26.
The turnover rates of low density lipoprotein-apolipoprotein B (LDL-apoB) were determined in 32 men with coronary heart disease (CHD) and 11 control men with normal plasma lipids. Thirty patients with CHD had normal levels of LDL-cholesterol (LDL-C); of these patients, 9 had hypertriglyceridemia and 21 had normal plasma lipids. Mean concentrations of total cholesterol and LDL-C were similar among the control subjects and CHD patients, although the latter had significantly lower HDL-C. In control subjects, transport rates and fractional catabolic rates (FCR) of LDL-B were 10.6 +/- 0.5 (SEM) mg/kg-day and 0.31 +/- 0.01 pools/day, respectively. In 10 hypertriglyceridemic patients with CHD, transport rates were 21.7 +/- 1.7 mg/kg-day, and FCRs averaged 0.56 +/- 0.06 pools/day; both were significantly higher than normal (P less than 0.05). Six normolipidemic patients also had abnormally high transport rates of LDL-apoB (19.4 +/- 2.8 mg/kg-day) and FCRs (0.51 +/- 0.03 pools/day); again both were higher than normal. The remaining 16 normolipidemic patients with CHD had normal transport rates (9.9 +/- 0.6 mg/kg-day) and FCRs (0.28 +/- 0.01 pools/day). Thus, hypertriglyceridemic patients with CHD and a portion of normolipidemic patients with CHD were characterized by increases in both transport and fractional catabolic rate of LDL-apoB; these abnormalities in LDL metabolism may have contributed to their coronary heart disease. However, the majority of normolipidemic patients with CHD did not show a distinct defect in their LDL metabolism.
在32名冠心病（CHD）男性患者和11名血脂正常的对照男性中测定了低密度脂蛋白-载脂蛋白B（LDL-apoB）的周转率。30名冠心病患者的低密度脂蛋白胆固醇（LDL-C）水平正常；在这些患者中，9名患有高甘油三酯血症，21名血脂正常。尽管冠心病患者的高密度脂蛋白胆固醇（HDL-C）显著较低，但对照组和冠心病患者的总胆固醇和LDL-C平均浓度相似。在对照组中，LDL-B的转运率和分数分解代谢率（FCR）分别为10.6±0.5（SEM）mg/kg-天和0.31±0.01池/天。在10名患有冠心病的高甘油三酯血症患者中，转运率为21.7±1.7 mg/kg-天，FCR平均为0.56±0.06池/天；两者均显著高于正常水平（P<0.05）。6名血脂正常的患者LDL-apoB的转运率（19.4±2.8 mg/kg-天）和FCR（0.51±0.03池/天）也异常高；同样两者均高于正常水平。其余16名患有冠心病的血脂正常患者的转运率（9.9±0.6 mg/kg-天）和FCR（0.28±0.01池/天）正常。因此，患有冠心病的高甘油三酯血症患者和部分患有冠心病的血脂正常患者的特征是LDL-apoB的转运和分数分解代谢率均增加；LDL代谢的这些异常可能导致了他们的冠心病。然而，大多数患有冠心病的血脂正常患者在LDL代谢方面并未表现出明显缺陷。
