Kesäniemi Y A, Beltz W F, Grundy S M
J Clin Invest. 1985 Aug;76(2):586-95. doi: 10.1172/JCI112010.
This study was designed to examine the integrated metabolism of apolipoprotein B (apo B) in very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), and low density lipoproteins (LDL) in normal subjects, obese patients, and a group of patients with coronary heart disease (CHD). Turnover rates of 131I-VLDL-B, 131I-IDL-B, 125I-LDL-B, and [3H]VLDL-triglycerides (TG) were determined by the multicompartmental analysis that used the model described in the preceding article (Beltz, W.F., et al. 1985. J. Clin. Invest. 76: 575-585). Compared with five normal subjects, four obese subjects had increased synthesis rates of both VLDL-B and VLDL-TG. Production of LDL-B was inconsistently raised in these same patients. Five patients with CHD had enhanced production of both VLDL-B and LDL-B, but secretion rates of VLDL-TG were not increased. Thus, in patients with obesity and in those with CHD, synthesis rates of VLDL particles may be abnormally high. In the obese patients, the VLDL appeared to be of normal composition, but in patients with CHD, the VLDL were relatively poor in TG. The study also showed that a significant fraction of VLDL-B is removed directly from the circulation and never reaches LDL regardless of the type of patients. The fraction that does reach LDL is one factor that determines LDL concentrations.
本研究旨在检测正常受试者、肥胖患者及一组冠心病（CHD）患者极低密度脂蛋白（VLDL）、中间密度脂蛋白（IDL）和低密度脂蛋白（LDL）中载脂蛋白B（apo B）的整合代谢情况。通过使用前文所述模型（Beltz, W.F., 等人，1985年。《临床研究杂志》76: 575 - 585）的多室分析方法，测定了131I - VLDL - B、131I - IDL - B、125I - LDL - B及[3H]VLDL - 甘油三酯（TG）的周转率。与5名正常受试者相比，4名肥胖受试者的VLDL - B和VLDL - TG合成率均升高。在这些相同患者中，LDL - B的生成量升高情况并不一致。5名冠心病患者的VLDL - B和LDL - B生成均增强，但VLDL - TG的分泌率未升高。因此，在肥胖患者和冠心病患者中，VLDL颗粒的合成率可能异常升高。在肥胖患者中，VLDL的组成似乎正常，但在冠心病患者中，VLDL的TG含量相对较低。该研究还表明，无论患者类型如何，相当一部分VLDL - B直接从循环中清除，从未进入LDL。进入LDL的部分是决定LDL浓度的一个因素。
